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Handling punctate keratitis resulting from systemic cytarabine

Handling punctate keratitis resulting from systemic cytarabine

Annals of Ophthalmology 25(8): 290-291

A young patient with acute myelogenous leukemia was treated with high-dose cytarabine (3.0 g/m2 every 12 hours). After five days of treatment, he developed severe photophobia and decreased visual acuity. On examination, progressive punctate keratitis was found. We discuss the mechanism of the cytarabine-induced corneal toxicity and the prophylactic use of topical corticosteroids.

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Accession: 046211512

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PMID: 8239322

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