+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Hantavirus infections in the United States: diagnosis and treatment

Hantavirus infections in the United States: diagnosis and treatment

Advances in Experimental Medicine and Biology 394: 153-162

Definitive diagnosis of acute hantavirus infection requires demonstration of specific IgG and IgM antibodies and a compatible clinical course; most persons with acute illness will also have viral RNA in PBMC which can be detected after RT-PCR amplification. Characteristic hematologic and hemodynamic findings are helpful in establishing a presumptive diagnosis of HPS in persons with cardiopulmonary symptoms and signs while awaiting the results of serologic testing and PCR. Diagnosis during the prodromal phase is difficult although very limited data suggest that most these patients also have hantavirus IgG and IgM antibodies. Patients with suspected hantavirus infection should be treated in a critical care unit, as sudden hemodynamic deterioration can occur at any time. Hemodynamic monitoring is encouraged in patients with cardiopulmonary symptoms and signs, and inotropic support and vasopressors should be used rather than fluids. An uncontrolled study of ribavirin therapy was inconclusive and a placebo-controlled trial is therefore planned. The latter study aims to enroll persons with prodromal findings and early cardiopulmonary disease.

(PDF emailed within 1 workday: $29.90)

Accession: 046211876

Download citation: RISBibTeXText

PMID: 8815682

Related references

Twenty-year summary of surveillance for human hantavirus infections, United States. Emerging Infectious Diseases 19(12): 1934-1937, 2014

Phylogenetically distinct hantavirus implicated in a case of hantavirus pulmonary syndrome in the northeastern United States. Journal Of Medical Virology. 46(1): 21-27, 1995

Diagnosis and treatment of new world hantavirus infections. Current Opinion in Infectious Diseases 19(5): 437-442, 2006

Mental health in the United States. Prevalence of diagnosis and medication treatment for attention-deficit/hyperactivity disorder--United States, 2003. Mmwr. Morbidity and Mortality Weekly Report 54(34): 842-847, 2005

Hantavirus infections for the clinician: from case presentation to diagnosis and treatment. Critical Reviews in Microbiology 38(4): 317-329, 2013

Uncomplicated skin and skin structure infections in children: diagnosis and current treatment options in the United States. Clinical Pediatrics 47(3): 211-219, 2008

Hantavirus transmission in the United States. Emerging Infectious Diseases 3(3): 361-365, 1997

Hantavirus Pulmonary Syndrome in the United States. Current Infectious Disease Reports 3(3): 258-265, 2001

Recognition and diagnosis of Cryptococcus gattii infections in the United States. Emerging Infectious Diseases 18(6): 1012-1015, 2012

Update: hantavirus disease--United States, 1993. Canada Communicable Disease Report 19(18): 157-158, 1993

Hantavirus infection in the United States: epizootiology and epidemiology. Reviews of Infectious Diseases 12(3): 449-457, 1990

Hantavirus pulmonary syndrome--United States, 1993. Mmwr. Morbidity and Mortality Weekly Report 43(3): 45-48, 1994

Update: Hantavirus infection - United States, 1993. Morbidity and Mortality Weekly Report 42(26): 517-519, 1993