+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hepatic complications in parenteral nutrition

Hepatic complications in parenteral nutrition

Zeitschrift für Gastroenterologie 34(1): 36-40

During parenteral nutrition hepatic complications are seen in about 15% of patients. They are characterized by steatosis, cholestasis and formation of sludge and bile stones. These hepatic complications depend on the duration as well as on the concept and mode of application of parenteral nutrition. They are more frequent after treatment periods of > 1-2 weeks, in response to a carbohydrate rich and low fat parenteral nutrition and in patients with extensive intestinal resection. Clinically, hepatic complications are frequently observed in new-borns and children, patients with inflammatory bowel disease, after ileum resection and in patients with hepatic malignancies. The exact pathophysiology of these phenomena is presently unknown. Enteral instead of parenteral nutrition, meeting the demand of nutrients, increasing fat supply (up to 50% of energy supply), "cyclic" parenteral nutrition and the addition of "semi-essential" nutrients (like L-glutamine, carnitin, cholin) are considered as possible strategies for the prevention and therapy of hepatic complications during parenteral nutrition.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 046237507

Download citation: RISBibTeXText

PMID: 8776174

Related references

Liver and nutrition hepatic complications of total parenteral nutrition. Lebenthal, E (Ed ) Textbook Of Gastroenterology And Nutrition in Infancy, Vols 1 And 2 Gastrointestinal Development And Perinatal Nutrition(Vol 1); Gastrointestinal Disease And Nutritional Inadequacies(Vol 2) Xxviii+670p (Vol 1); Xix+463p (Vol 2) Raven Press: New York, N Y , Usa Illus P743-764, 1981

Hepatic complications of parenteral nutrition. Clinical Nutrition 14(Suppl. 1): 59-64, 1995

Hepatic complications of total parenteral nutrition. American Journal of Medicine 82(3): 489-497, 1987

Hepatic and biliary complications during parenteral nutrition. Revue Medicale de la Suisse Romande 104(3): 219-223, 1984

Hepatic complications of total parenteral nutrition. Journal of Parenteral and Enteral Nutrition 12(6): 615-618, 1988

Parenteral nutrition in a bone marrow transplant patient with hepatic complications. Nutrition in Clinical Practice 5(1): 18-22, 1990

HLA, GVHD, and parenteral nutrition are risk factors for hepatic complications in pediatric HSCT. Pediatric Transplantation 20(1): 96, 2016

Hepatic complications in subjects subjected to total parenteral nutrition with glycoside and lipid solutions. Giornale di Clinica Medica 68(6-7): 391-392, 1987

Reduction of complications associated with total parenteral nutrition by introduction of a clinical monitoring team. The Total Parenteral Nutrition Committee. Australian Clinical Review 11(4): 138-142, 1991

Consultative total parenteral nutrition teams: the effect on the incidence of total parenteral nutrition-related complications. Jpen. Journal of Parenteral and Enteral Nutrition 8(2): 146-152, 1984

Severe liver complications associated with long-term parenteral nutrition are dependant on lipid parenteral input. Gastroenterology 112(4 Suppl. ): A864, 1997

Severe liver complications associated with long-term parenteral nutrition are dependent on lipid parenteral input. Transplantation Proceedings 30(6): 2547, 1998

Hepatic function during short-term total parenteral nutrition: effect of exposure of parenteral nutrients to light. Research Communications in Chemical Pathology and Pharmacology 78(3): 321-340, 1992

Biological hepatic abnormalities, cholestatic jaundice and hospital artificial nutrition. A comparative study in adults with cyclic total parenteral nutrition and enteral nutrition. Gastroenterologie Clinique et Biologique 12(4): 326-331, 1988

Effect of decreased parenteral soybean lipid emulsion on hepatic function in infants at risk for parenteral nutrition-associated liver disease: a pilot study. Journal of Pediatric Surgery 48(6): 1348-1356, 2013