+ Translate
+ Most Popular
Spermatogenic and steroidogenic impairment after chromium treatment in rats
Prediction of enthalpy of formation based on refined crystal structures of multisite compounds; Part 1, Theories and examples
Intrastromal photorefractive keratectomy for myopia by Nd:YLF picosecond laser
Teachers' beliefs about the role of prior language knowledge in learning and how these influence teaching practices
Classification and genesis of submarine iron-manganese deposits
Insecta a Cl. G. N. Potanin in China et in Mongolia novissime lecta. XVII. Hemiptera-Heteroptera
On the occurrence of the splendid genus Machaerothrix Haupt in Tsushima, with some remarks on the genus (Hymenoptera, Pompilidae)
Enamel craze lines
Gynecologic examination of the child and the adolescent
Periosteal osteoclasts, skeletal development and ageing
Fibrodysplasia ossificans progressiva in a Nigerian: a case report
The chronically ill patient with anorexia nervosa development, phenomenology, and therapeutic considerations
Kummelonautilus taiwanum sp. nov. (Nautilida) from the early Miocene Shihmen Formation, Chungliao, Nantou, west-central Taiwan
Efficacy of Droncit against Dipylidium caninum in dogs
Pierids of the genus Euchloe Klots (Lepidoptera, Pieridae) from Siberia and the Far East.
C5A anaphylatoxin and its seven transmembrane-segment receptor
Failure to practice evidence-based medicine: why do physicians not treat patients with heart failure with angiotensin-converting enzyme inhibitors?
Empirical comparisons of proportional hazards regression, Poisson regression, and logistic regression in the analysis of occupational cohort data
Pollination of flowers of sweet and sour cherries
Isopodi terrestri raccolti nell' Estremo Oriente
Morphometric observations on Dipylidium caninum from dogs and cats in Austria
Chelation effectiveness of zinc proteinates demonstrated
Alopecia--a psychosomatic disease picture? I. Review of the literature
Monitoring equity in health and healthcare: a conceptual framework
Hemodynamic evaluation of the Biocor heterologous prosthesis

Histopathologic study of veins in steroid treated rabbits

Histopathologic study of veins in steroid treated rabbits

Clinical Orthopaedics and Related Research 334: 37-42

ISSN/ISBN: 0009-921X

PMID: 9005894

Although arterial factors have been regarded as playing an important role in the pathogenesis of osteonecrosis, more attention has been given to venous factors because steroids cause an increase in the intraosseous pressure despite a decrease in blood flow in the femoral head. The authors examined changes in the veins of steroid treated rabbits. Forty rabbits were used: 30 rabbits (the steroid treated group) were injected with methylprednisolone acetate (4 mg/kg) weekly and 10 rabbits (the control group) were treated without steroids. The veins around the femoral head, ear veins, femoral veins, and inferior vena cava were obtained after 8 weeks of treatment, and the specimens were examined by immunohistochemical staining and electron microscopy. In the steroid treated group, proliferation of foam cells was observed in the intima of the vein in 7 of 30 rabbits. Immunohistochemical studies, using monoclonal antibodies for smooth muscle cells and macrophages, showed that the foam cells were derived from smooth muscle cells. Electron microscopy showed damage to the endothelial cells and smooth muscle cells. These results indicated that corticosteroids damaged the venous system. It is suggested that steroid induced disturbance of the draining veins causes stasis and that steroids are an important factor in osteonecrosis of the femoral head.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 046260238

Download citation: RISBibTeXText

Related references

Histopathologic study of veins in steroid treated rabbits. International Symposium on Bone Circulation (334): 37-42, 1997

Ovarian steroid secretion in estrous, mated and HCG-treated rabbits, determined by concurrent cannulation of both ovarian veins. Biology of Reproduction 7(3): 387-397, 1972

The cortico steroid fractions of bone marrow of intact rabbits and rabbits treated with ammonium chloride with special consideration of seasonal changes. Endokrinologie: 325-332, 1972

Studies on experimental steroid glaucoma. Report 6. The relation between intraocular pressure and aqueous levels of cAMP in steroid-treated young rabbits' eyes. Nippon Ganka Gakkai Zasshi 84(10): 1738-1745, 1980

Periovulatory steroid concentrations in HCG-treated rabbits. Hormone Research 9(1): 26-30, 1978

Histopathologic examination of the genital tract in rabbits treated once or twice with a slow-release deslorelin implant for reversible suppression of ovarian function. Theriogenology 86(9): 2281-2289, 2016

Changes in the concentrations of plasma steroid hormone and plasma 13 14 di hydro 15 oxo prostaglandin f 2 alpha in late pregnancy rabbits treated with an inhibitor of 3 alpha hydroxy steroid dehydrogenase. Endocrinologia Japonica 31(3): 349-354, 1984

Intraosseous pressure and outflow resistance in steroid treated rabbits. Arthritis and Rheumatism 28(4 Suppl): S87, 1985

Decidual cell responses in sex-steroid-treated rabbits Deciduosarcomas or deciduosis. Toxicologic Pathology 28(6): 856-857, 2000

Lovastatin inhibits adipogenesis and prevents osteonecrosis in steroid-treated rabbits. Joint Bone Spine 75(6): 696-701, 2008

The response of osteocytes to a lipid clearing agent in steroid-treated rabbits. Journal of Bone and Joint Surgery. British Volume 73(6): 911-915, 1991

Risk factors for developing osteonecrosis after prophylaxis in steroid-treated rabbits. Journal of Rheumatology 35(12): 2391-2394, 2008

Effect of surgical technique on intestinal anastomotic healing in steroid-treated rabbits. Digestive Surgery 13(3): 205-208, 1996

Synovial regeneration and articular cartilage changes after synovectomy in normal and steroid-treated rabbits. Journal of Bone and Joint Surgery. British Volume 57(4): 454-462, 1975

Preservation of Femoral Head Blood Circulation with Lovastatin in Steroid Treated Rabbits. Journal of Musculoskeletal Research 01(01): 13-19, 1997