+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis

Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis

Current Opinion in Microbiology 2(4): 403-409

A general association of human and primate lymphotropic herpesviruses (gamma-herpesviruses) with the development of lymphomas, as well as other tumors, especially in immunocompromised hosts, has been well documented. The lack of relevant small animal models for human gamma-herpesviruses has impeded progress in understanding the role of these viruses in the development of chronic disease. Recent research characterizing infection of inbred strains of mice with a murine gamma-herpesvirus, gamma-herpesvirus 68 (gammaHV68), is providing insights into viral and host factors involved in the establishment and control of chronic gamma-herpesvirus infection.

(PDF emailed within 0-6 h: $19.90)

Accession: 046274728

Download citation: RISBibTeXText

PMID: 10458986

DOI: 10.1016/s1369-5274(99)80071-x

Related references

The pathogenesis of equine herpesvirus type 1 in the mouse: a new model for studying host responses to the infection. Journal of General Virology 71: 1131-1140, 1990

A novel model to study the viral pathogenesis of multiple sclerosis after infection with human herpesvirus-6. Annals of Neurology 54(Suppl 7): S47-S48, 2003

Pathogenesis of equine herpesvirus-1 infection in the mouse model. Apmis 117(1): 10-21, 2009

Felid herpesvirus type 1 infection in cats: a natural host model for alphaherpesvirus pathogenesis. Isrn Veterinary Science 2012: 495830, 2012

Gamma delta+ T cells involvement in viral immune control of chronic human herpesvirus 8 infection. Journal of Immunology 180(5): 3417-3425, 2008

Comparison of the pathogenesis of acute equine herpesvirus 1 (EHV-1) infection in the horse and the mouse model: A review. Veterinary Microbiology 68(1-2): 3-13, 1999

The role of viral and host genetics in natural history and treatment of chronic HCV infection. Best Practice and Research. Clinical Gastroenterology 26(4): 413-427, 2013

Murine herpesvirus pathogenesis: a model for the analysis of molecular mechanisms of human gamma herpesvirus infections. Acta Microbiologica et Immunologica Hungarica 52(1): 41-71, 2005

The guinea pig as a model of the pathogenesis of varicella zoster virus infection and of the host response to viral proteins. Journal of Cellular Biochemistry Supplement (14 PART D): 44, 1990

Host genetics play a critical role in controlling CD8 T cell function and lethal immunopathology during chronic viral infection. Plos Pathogens 13(7): E1006498, 2017

Adaptation of human influenza H3N2 virus in a mouse pneumonitis model: insights into viral virulence, tissue tropism and host pathogenesis. Microbes and Infection 11(1): 2-11, 2008

Enhanced atherogenesis is not an obligatory response to systemic herpesvirus infection in the apoE-deficient mouse: comparison of murine gamma-herpesvirus-68 and herpes simplex virus-1. Arteriosclerosis, Thrombosis, and Vascular Biology 22(5): 793-798, 2002

Mouse genetics at work: a new model of chronic hepadnavirus infection. Hepatology 28(1): 268-269, 1998

Pathogenesis of an infectious mononucleosis-like disease induced by murine gamma-herpesvirus: Role for a viral superantigen?. Journal of Experimental Medicine 185(9): 1641-1650, 1997

Co-infection of malaria and gamma-herpesvirus: exacerbated lung inflammation or cross-protection depends on the stage of viral infection. Clinical and Experimental Immunology 138(3): 396-404, 2004