+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Host cell invasion by the opportunistic pathogen Toxoplasma gondii

Host cell invasion by the opportunistic pathogen Toxoplasma gondii

Acta Tropica 81(2): 111-122

Toxoplasma gondii is an obligate intracellular protozoan that infects an astonishing variety of vertebrate hosts including humans. Classified in the phylum Apicomplexa, T. gondii causes an opportunistic disease, toxoplasmosis, in individuals with immune dysfunction and congenital disease in infected infants. Re-emergence of toxoplasmosis as a life-threatening disease in patients with AIDS is anticipated in the wake of emerging multi-drug resistant strains of HIV. In immunodeficient patients, the available evidence suggests that tissue pathology associated with T. gondii infection is due to parasite-directed lytic destruction of individual host cells. The Toxoplasma lytic cycle begins when the parasite actively invades a target cell. In association with invasion, T. gondii sequentially discharges three sets of secretory organelles beginning with the micronemes, which contain adhesive proteins involved in parasite attachment to a host cell. Deployed as protein complexes, several micronemal proteins possess vertebrate-derived adhesive sequences that function in binding receptors on the surface of a target cell. Each protein in these adhesive complexes fulfills a specific role in movement through the secretory pathway, targeting to the micronemes, or adhesion. It is anticipated that these adhesive complexes recognize a variety of host receptors, including some that are expressed on multiple cell types, and that this diversity in host cell receptors contributes to the remarkably broad tissue- and host-range of T. gondii.

(PDF emailed within 0-6 h: $19.90)

Accession: 046274741

Download citation: RISBibTeXText

PMID: 11801218

DOI: 10.1016/s0001-706x(01)00201-7

Related references

The opportunistic pathogen Toxoplasma gondii deploys a diverse legion of invasion and survival proteins. Journal of Biological Chemistry 280(40): 34233-34244, 2005

Laser scanning cytometer-based assays for measuring host cell attachment and invasion by the human pathogen Toxoplasma gondii. Cytometry. Part a 69(1): 13-19, 2005

Host cell invasion by Toxoplasma gondii is temporally regulated by the host microtubule cytoskeleton. Eukaryotic Cell 9(11): 1680-1689, 2011

Host cell invasion by Toxoplasma gondii. Trends in Microbiology 6(1): 27-30, 1998

Biology of Toxoplasma gondii host cell entry: the role of recognition and attachment for invasion of host cells. Intracellular parasitism: 259-269, 1989

Host cell manipulation by the human pathogen Toxoplasma gondii. Cellular and Molecular Life Sciences 65(12): 1900-1915, 2008

Host cell ATP level and invasion of Toxoplasma gondii. Transactions of the Royal Society of Tropical Medicine and Hygiene 81(3): 377, 1987

Update on host cell invasion by Toxoplasma gondii. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 25(2): 154-157, 2007

The role of the cytoskeleton in host cell invasion by Toxoplasma gondii. Behring Institute Mitteilungen: 90-96, 1997

Secretion from the rhoptries of Toxoplasma gondii during host-cell invasion. Journal of ultrastructure research 83(1): 85-98, 1983

Subcellular organelles of Toxoplasma gondii and host cell invasion. Research in Immunology 144(1): 31-33, 1993

Ultrastructural study of the invasion of the host cell by toxoplasma gondii. Journal of Protozoology 29(2): 304, 1982

MIC6 associates with aldolase in host cell invasion by Toxoplasma gondii. Parasitology Research 105(2): 441-445, 2009

Secretory organelles of Toxoplasma gondii Their role in host cell invasion. Postepy Biologii Komorki 30(3): 515-524, 2003

Invasion of Toxoplasma gondii occurs by active penetration of the host cell. Journal of Cell Science 108: 2457-2464, 1995