+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Host cell surface sialic acid residues are involved on the process of penetration of Toxoplasma gondii into mammalian cells



Host cell surface sialic acid residues are involved on the process of penetration of Toxoplasma gondii into mammalian cells



Fems Microbiology Letters 164(2): 323-327



Tachyzoites of Toxoplasma gondii are able to infect several cell types tested (wild-type chinese hamster ovary (CHO) cells and glycosylation mutants, Vero and LLCMK2 cells). However, the extent of infection varied. Mutant cells which present few or no surface-exposed sialic acid residues were infected to a lower extent. Similar results were obtained if sialic acid residues were removed by previous neuraminidase treatment. Addition of sialic acid residues to surface-exposed glycoconjugates using fetuin as a sialic acid donor and the trans-sialidase of Trypanosoma cruzi rendered the cells more easily infected by Toxoplasma gondii. These observations indicate that surface-exposed carbohydrate residues of the host cell are involved on the process of Toxoplasma gondii-host cell recognition.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 046274748

Download citation: RISBibTeXText

PMID: 9682481

DOI: 10.1111/j.1574-6968.1998.tb13105.x


Related references

Sialic acid residues of host cell are involved in the process of Toxoplasma gondii penetration. Memorias do Instituto Oswaldo Cruz 92(Suppl. 1): 79, 1997

Characterization of the phospholipase involved in toxoplasma gondii host cell penetration. Journal of Cellular Biochemistry Suppl. (13 Part E): 148, 1989

Lysosomes of Toxoplasma gondii and their possible relation to the host-cell penetration of toxoplasma parasites. Journal of Bacteriology 96(4): 916-919, 1968

Interactions between Toxoplasma gondii and its host cells: function of the penetration-enhancing factor of toxoplasma. Infection and Immunity 11(4): 853-861, 1975

Demonstration of a factor of Toxoplasma gondii enhancing the penetration of toxoplasma parasites into cultured host cells. Brit J Exp Pathol 47(3): 248-256, 1966

Toxoplasma gondii glycosylphosphatidylinositols are not involved in T. gondii-induced host cell survival. Apoptosis 12(4): 781-790, 2007

Cell surface molecules of trophoblast cells involved in adhesion of Toxoplasma gondii. Clinical & Experimental Metastasis 14(Suppl. 1): 29, 1996

Host Cell Penetration of Toxoplasma gondii. Infection and Immunity 2(3): 250-255, 1970

Host cell penetration of toxoplasma gondii. Journal of Protozoology 19(Suppl.): 14, 1972

Molecular partitioning during host cell penetration by Toxoplasma gondii. Traffic 5(11): 855-867, 2004

A soluble phospholipase of Toxoplasma gondii associated with host cell penetration. Journal of Protozoology 385: 454-460, 1991

Factors enhancing the host-cell penetration of Toxoplasma gondii. Journal of Bacteriology 93(1): 53-58, 1967

The role of phospholipase in host cell penetration by Toxoplasma gondii. American Journal of Tropical Medicine and Hygiene 40(2): 145-149, 1989

The distribution pattern of α2,3- and α2,6-linked sialic acids affects host cell preference in Toxoplasma gondii. Experimental Parasitology 155: 74-81, 2015

Sialic acid residues exposed on mammalian cell surface: the effect of adsorption of denatured virus particles. Biochemical and Biophysical Research Communications 57(1): 271-278, 1974