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Host control of yeast dsRNA virus propagation and expression



Host control of yeast dsRNA virus propagation and expression



Trends in Microbiology 1(8): 294-299



Yeast controls propagation of the L-A dsRNA virus, and thus pathogenicity, by partially blocking translation of viral mRNA. L-A makes a Gag-Pol fusion protein by a -1 ribosomal frameshift, regulated by the host but critical for satellite RNA propagation. Discovery of the KEX proteases, by their requirement for killer toxin expression from a satellite dsRNA of L-A, led to the identification of mammalian prohormone processing proteases.

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Accession: 046274759

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PMID: 8162413

DOI: 10.1016/0966-842X(93)90005-C


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