+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele



Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele



Emerging Infectious Diseases 3(3): 261-271



Since the late 1970s, 8.4 million people worldwide, including 1.7 million children, have died of AIDS, and an estimated 22 million people are infected with human immunodeficiency virus (HIV)(1). During 1995 and 1996, major clinical and laboratory discoveries regarding HIV pathogenesis provided new hope for the prevention and treatment of HIV infection. One major discovery was that members of the chemokine receptor family serve as cofactors for HIV entry into cells. We describe the role of allelic polymorphism in the gene coding for the CCR5 chemokine receptor with regard to susceptibility to and disease course of HIV infection. We also examine the effect of this discovery on medical and public health practices.

(PDF emailed within 0-6 h: $19.90)

Accession: 046274819

Download citation: RISBibTeXText

PMID: 9284370

DOI: 10.3201/eid0303.970302


Related references

Distribution of human chemokine (C-X3-C) receptor 1 (CX3CR1) gene polymorphisms and haplotypes of the CC chemokine receptor 5 (CCR5) promoter in Chinese people, and the effects of CCR5 haplotypes on CCR5 expression. International Journal of Immunogenetics 32(2): 99-106, 2005

Biological consequences of chemokine receptor polarization on TH1 and TH2 cells from individuals wildtype for CCR5 or homozygous for the DELTA32 CCR5 allele. Blood 92(10 SUPPL 1 PART 1-2): 21A, Nov 15, 1998

Sequence of chemokine receptor gene CCR5 in chimpanzees, a natural HIV type 1 host. Aids Research and Human Retroviruses 13(13): 1159-1161, 1997

Gene conversion between mammalian CCR2 and CCR5 chemokine receptor genes: a potential mechanism for receptor dimerization. Genomics 90(2): 213-224, 2007

Role of the chemokine receptor CCR5-dependent host defense system in Neospora caninum infections. Parasites and Vectors 8: 5, 2016

Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine-CCR5 interactions. Antiviral Therapy 15(3): 321-331, 2010

The chemokine receptor CCR5 Δ32 allele in natalizumab-treated multiple sclerosis. Acta Neurologica Scandinavica 129(1): 27-31, 2014

Allele frequency of the CCR5 mutant chemokine receptor in Greek Caucasians. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 17(2): 181-182, 1998

Controversial role of smallpox on historical positive selection at the CCR5 chemokine gene (CCR5-Delta 32). Journal of Infection in Developing Countries 3(4): 324-326, 2009

Schizophrenia and cancer risk: can the CCR5-delta 32 chemokine receptor gene mutation play a role?. Medical Hypotheses 67(2): 427-428, 2006

A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation. Nature Medicine 4(3): 350-353, 1998

Role of CCR5 chemokine receptor gene in vertical human immunodeficiency virus type 1 transmission and disease progression. Pediatric Infectious Disease Journal 17(9): 847-849, 1998

Prevalence and sequence of the beta-chemokine receptor CCR5-DELTA32 deletion allele in the Lebanese population. FASEB Journal 17(4-5): Abstract No 366 8, 2003

A novel chemokine-receptor-5 (CCR5) blocker, SCH532706, has differential effects on CCR5+CD4+ and CCR5+CD8+ T cell numbers in chronic HIV infection. Aids Research and Human Retroviruses 26(6): 653-661, 2010

Chemokine receptor CCR5 mediates alloimmune responses in graft-versus-host disease. Biology of Blood and Marrow Transplantation 16(3): 311-319, 2010