+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Host response and Histoplasma capsulatum/macrophage molecular interactions



Host response and Histoplasma capsulatum/macrophage molecular interactions



Medical Mycology 38(6): 399-406



Histoplasma capsulatum is the etiological agent of histoplasmosis, a chronic respiratory infection that is generally asymptomatic in healthy individuals, but severe or fatal in patients who are immunosuppressed or otherwise debilitated. H. capsulatum is found as a mould in soil and becomes a pathogenic yeast in the mammalian host. The first line of defense that H. capsulatum faces during host invasion is the attack of polymorphonuclear neutrophils and resident macrophages. In animal models, once phagocytosed, H. capsulatum is not killed by fusion of the phago-lysosomes, instead it multiplies within non-activated macrophages and destroys them. Upon induction of cell-mediated immunity, cytokines activate macrophages and destroy the yeast cells. Some aspects of the fungus-macrophage interaction have been elucidated, and it is clear that some of the mechanisms by which H. capsulatum escapes the lethal effects of this very hostile environment, involve the regulation of specific genes. Recently, using the differential display reverse transcriptase polymerase chain reaction technique, a number of H. capsulatum genes that are induced after the yeasts are ingested by macrophages have been identified. However, the mechanisms that underlie the capacity of H. capsulatum to adapt to the new environmental conditions present in macrophages remain to be clarified.

(PDF emailed within 1 workday: $29.90)

Accession: 046274906

Download citation: RISBibTeXText

PMID: 11204877


Related references

In vitro production of extracellular elastolytic proteinase by Histoplasma capsulatum var. duboisii and Histoplasma capsulatum var. capsulatum in the yeast phase. Mycoses 34(11-12): 461-467, 1991

Production of extracellular collagenolytic proteinases by Histoplasma capsulatum var. duboisii and Histoplasma capsulatum var. capsulatum in the yeast phase. Mycoses 34(11-12): 453-460, 1991

In vitro activity of itraconazole (R-51211) against Paracoccidioides brasiliensis, Histoplasma capsulatum var. capsulatum and Histoplasma capsulatum var. duboisii. Anais Brasileiros de Dermatologia 63(3): 299-302, 1988

Interleukins 17 and 23 influence the host response to Histoplasma capsulatum. Journal of Infectious Diseases 200(1): 142-151, 2009

Platelet phagocytosis A novel host response to Histoplasma capsulatum. Clinical Infectious Diseases 25(2): 380, 1997

Soluble mediators in the host response to Histoplasma capsulatum. Domer, J E , Reprint Author, Kobayashi, G S Human fungal pathogens: 207-223, 2004

Neutralization of endogenous granulocyte-macrophage colony-stimulating factor subverts the protective immune response to Histoplasma capsulatum. Journal of Immunology 163(9): 4985-4993, 1999

Production of extracellular proteolytic activity by Histoplasma capsulatum grown in Histoplasma-macrophage medium is limited to restriction fragment length polymorphism class 1 isolates. Diagnostic Microbiology and Infectious Disease 59(1): 39-47, 2007

Molecular characterization of autochthonous clinical isolates of Histoplasma capsulatum var. capsulatum using RAPD-PCR. Revista Argentina de Microbiologia 33(3): 160-166, 2001

Molecular detection of Histoplasma capsulatum var. capsulatum in human clinical samples. Journal of Clinical Microbiology 41(4): 1753-1755, 2003

Subcutaneous and systematic mycoses (Subkutane und System-Mykosen). Global distribution of Histoplasma capsulatum (Globale Verbreitung von Histoplasma capsulatum). World Atlas of Epidemic Diseases (Welt-Seuchen-Atlas). 3: III/133-III/134, 1959

Comparative Fluorescent Antibody Staining Of Histoplasma Capsulatum And Histoplasma Duboisii With A Specific Anti-Yeast Phase H. Capsulatum Conjugate. Mycopathologia et Mycologia Applicata 24: 315-326, 1964

Effect of macrophage colony-stimulating factor (M-CSF) on macrophage morphology, phagocytosis, and intracellular multiplication of Histoplasma capsulatum. International Journal of Immunopharmacology 16(2): 171-176, 1994

Rapid diagnosis of Histoplasma capsulatum endocarditis using the Histoplasma capsulatum AccuProbe directly on the excised valve. Abstracts of the General Meeting of the American Society for Microbiology 101: 239, 2001

Laboratory studies of Histoplasma capsulatum. III. Efficiency of the flotation method in isolation of Histoplasma capsulatum from soil. Journal of Laboratory and Clinical Medicine 41(3): 478-485, 1953