+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Host susceptibility factors in mycobacterial infection. Genetics and body morphotype



Host susceptibility factors in mycobacterial infection. Genetics and body morphotype



Infectious Disease Clinics of North America 16(1): 163-186



Through identification and evaluation of mutations and polymorphisms in components of the IFN gamma response pathways, a better understanding of the mechanisms and risk factors influencing the development of mycobacterial disease is gained. This may lead the way for development of therapeutic and preventative strategies. Although conventional science has focused on identifying discrete mutations, greater awareness of the impact of subtle changes, both at the genetic (polymorphisms) and physical levels (body morphotype), may prove critical in the investigative process. There has been extraordinary progress in the understanding of mycobacterial susceptibility factors over the last few years. The recognition of characteristic phenotypes will lead to the identification of new genetic bases for disease.

(PDF emailed within 0-6 h: $19.90)

Accession: 046274944

Download citation: RISBibTeXText

PMID: 11917812

DOI: 10.1016/S0891-5520(03)00051-5


Related references

Host genetics in susceptibility to and severity of mycobacterial diseases. Tuberculosis 106: 1-8, 2018

Susceptibility to mycobacterial infections: The importance of host genetics. Genes & Immunity 4(1): 4-11, January, 2003

Comparative host susceptibility studies in four salmonids toward infection with an un-usual Danish Gyrodactylus salaris morphotype. Acta Parasitologica 45(3): 270, July, 2000

Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility. Fish & Shellfish Immunology: -, 2018

Genetics and genomics of susceptibility to mycobacterial infection in cattle. Journal of Dairy Science 84(Supplement 1): 57, 2001

Acquired and genetic host susceptibility factors and microbial pathogenic factors that predispose to nontuberculous mycobacterial infections. Current Opinion in Immunology 54: 66-73, 2018

Host genetic factors in susceptibility to mycobacterial disease. Clinical Medicine 14 Suppl 6: S17-S21, 2016

Susceptibility to HIV infection--disentangling host genetics and host behavior. Journal of Infectious Diseases 193(1): 4-6, 2005

Joint effects of host genetic background and mycobacterial pathogen on susceptibility to infection. Infection and Immunity 79(6): 2372-2378, 2011

Genetics and nutrition of the host in relation to susceptibility to infection. Annals of the New York Academy of Sciences 66(1): 25-31, 1956

Cellular genetics of host susceptibility and resistance to virus infection. Critical Reviews in Eukaryotic Gene Expression 16(2): 155-170, 2006

Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. Journal of Infectious Diseases 193(1): 16-26, 2005

Familial disseminated atypical mycobacterial infection in childhood: A human mycobacterial susceptibility gene?. Lancet (North American Edition) 345(8942): 79-83, 1995

Host genetics and susceptibility to congenital and childhood cytomegalovirus infection: a systematic review. Croatian Medical Journal 57(4): 321-330, 2016

Genetics and nutrition of the host in relation to susceptibility to infection; In Epidemic and endemic diarrheal diseases of the infant. 1956