+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Host tissue damage by phagocytes



Host tissue damage by phagocytes



Annals of the New York Academy of Sciences 832: 426-448



Evidence continues to accumulate on the importance of neutrophils (PMNs) and phagocytes in the causation of tissue and endothelial injury that frequently accompanies the inflammatory response. Increased production of superoxide anions in combination with decreased endothelial antioxidant activity may contribute to the development of vascular disease including atherosclerosis, vasospasm, diabetic vascular complications, tissue damage in ischemia-reperfusion, and hypotension. Free radicals generated in the vascular wall may act directly on smooth muscle or interact with each other thus producing biologically active endogenous mediators. Derangement of macrophage function may occur in conditions characterized by protein malnutrition, thus leading to failure to develop a specific immunoresponse and to an increase in the production of oxygen intermediate radicals, which may cause tissue damage. A local inflammatory response followed by endothelial cell activation could also facilitate migration of immunocompetent cells into the parenchyma of grafted organs and stimulate dendritic cells in the graft. There is now convincing evidence that excessive and prolonged production of NO contributes to tissue damage in septicemia, ischemia/reperfusion injury, and other inflammatory conditions. There is also increasing evidence that the complement system plays an important role in tissue damage in association with phagocytes, e.g., in ischemia/reperfusion injury, carcinogenesis, and aging. It can therefore be surmised that phagocytic cells may act both as "friends" and as "foes" and that they are important mediators of tissue damage in a variety of conditions.

(PDF emailed within 1 workday: $29.90)

Accession: 046274946

Download citation: RISBibTeXText

PMID: 9704069


Related references

Influenza infection induces host DNA damage and dynamic DNA damage responses during tissue regeneration. Cellular and Molecular Life Sciences 72(15): 2973-2988, 2015

Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord. Brain 135(Pt 2): 447-460, 2012

Mediators of tissue damage in rheumatoid arthritis: phagocytes as secretory organs of rheumatoid inflammation. Triangle; the Sandoz Journal of Medical Science 18(2-3): 45-52, 1979

Tissue damage in cattle infected with Theileria annulata accompanied by metastasis of cytokine-producing, schizont-infected mononuclear phagocytes. Journal of Comparative Pathology 120(1): 39-57, 1999

Host-mediated tissue damage. Journal of Paediatrics and Child Health 30(4): 296-297, 1994

Roles of mononuclear phagocytes in host defense 2. roles of mononuclear phagocytes in the immune response. Biologia 28(2): 227-240, 1980

Mechanisms of host tissue damage by cytokine-activated neutrophils. Immunology Series 57: 499-521, 1992

Method for preventing tissue damage associated with graft-versus-host or host-versus-graft disease following transplantation. Official Gazette of the United States Patent & Trademark Office Patents 1237(1), Aug 1, 2000

Freezing adipose tissue grafts may damage their ability to integrate into the host. Connective Tissue Research 50(1): 14-28, 2009

The host response to invasion by Streptococcus pneumoniae: protection and the pathogenesis to tissue damage. Reviews of Infectious Diseases 3(2): 282-288, 1981

Mechanisms of tissue damage in human acute graft versus host disease. EOS-Rivista di Immunologia ed Immunofarmacologia 9(4): 214-219, 1989

Carcinoma cells misuse the host tissue damage response to invade the brain. Glia 61(8): 1331-1346, 2014

Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule. Official Gazette of the United States Patent & Trademark Office Patents 1250(2), Sep 11, 2001

Natural killer cell involvement in graft vs. host induced tissue damage. Federation Proceedings 44(4): 1316, 1985

Clinical implications of oral candidiasis: host tissue damage and disseminated bacterial disease. Infection and Immunity 83(2): 604-613, 2015