+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Human papillomavirus-11-associated recurrent respiratory papillomatosis is more aggressive than human papillomavirus-6-associated disease



Human papillomavirus-11-associated recurrent respiratory papillomatosis is more aggressive than human papillomavirus-6-associated disease



Pediatric and Developmental Pathology 4(1): 68-72



The aim of this study was to determine whether viral type (HPV-6 vs. HPV-11) could predict the clinical course of recurrent respiratory papillomatosis in children. Viral typing, using the polymerase chain reaction, was performed on laryngeal biopsies of 61 patients treated at Children's Hospital of Michigan. HPV-6 was detected in 29 of the patients' biopsies and HPV-11 in 32 biopsies. HPV-11 was more common among the African-American patients than among Caucasians (P = 0.001). Patients with HPV-11 were diagnosed at a younger age (36.2 vs. 48.2 months; P = 0.04) and were more likely to have active disease (P = 0.0311) at the time of this study. They tended to have longer periods of disease activity (8 years vs. 5 years; P = 0.026), required more surgical procedures (42 procedures/patient vs. 13.6; P = 0.02), and more procedures per patient, per year (2.9 vs. 5.3; P = 0.0164). Three of the patients infected with HPV-11 developed invasive papillomatosis and bronchogenic squamous cell carcinoma, and two of these patients died of disease. Our findings suggest that HPV-11 infection confers a more aggressive course to recurrent respiratory papillomatosis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 046290560

Download citation: RISBibTeXText

PMID: 11200493

DOI: 10.1007/s100240010105


Related references

Clinical course of recurrent respiratory papillomatosis: comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11. Head and Neck 37(11): 1625-1632, 2016

Malignant transformation of a highly aggressive human papillomavirus type 11-associated recurrent respiratory papillomatosis. American Journal of Otolaryngology 31(4): 291-296, 2010

Polymorphism of transporter associated with antigen presentation 1 as a potential determinant for severity of disease in recurrent respiratory papillomatosis caused by human papillomavirus types 6 and 11. Journal of Infectious Diseases 189(5): 871-879, 2004

Detection of human papillomavirus in the upper respiratory tract in children without recurrent respiratory papillomatosis. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 47(12): 974-977, 2014

The heterogeneous distribution of human papillomavirus activities in recurrent respiratory papillomatosis. Journal of Investigative Medicine 43(SUPPL 1): 1A, 1995

Detection and cloning of human papillomavirus DNA associated with recurrent respiratory papillomatosis in Thailand. Japanese Journal Of Cancer Research. 85(7): 699-703, 1994

Human papillomavirus infection in recurrent upper respiratory tract papillomatosis. Archiv fuer Geschwulstforschung 60(6): 429-434, 1990

Human papillomavirus genotype detection in recurrent respiratory papillomatosis (RRP) in Colombia. Head and Neck 35(2): 229-234, 2013

Human papillomavirus types causing recurrent respiratory papillomatosis in Zimbabwe. International Journal of Pediatric Otorhinolaryngology 116: 147-152, 2018

Molecular identification of 7 human papillomavirus types in recurrent respiratory papillomatosis. Archives of Otolaryngology--Head and Neck Surgery 126(9): 1119-1123, 2000

Divergent human papillomavirus associated with recurrent respiratory papillomatosis with lung involvement. Genome Announcements 1(4), 2013

Time course of juvenile onset recurrent respiratory papillomatosis caused by human papillomavirus. Pediatric Infectious Disease Journal 27(2): 149-154, 2008

Changes in human papillomavirus typing of recurrent respiratory papillomatosis progressing to malignant neoplasm. Archives of Otolaryngology--Head & Neck Surgery 120(11): 1273-1276, 1994

Recurrent respiratory papillomatosis: a complex defect in immune responsiveness to human papillomavirus-6 and -11. Apmis 118(6-7): 455-470, 2010

Novel HPV-6 variants of human papillomavirus causing recurrent respiratory papillomatosis in southern Africa. Epidemiology and Infection 140(6): 1095-1101, 2012