+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Immunity to heat shock proteins and pregnancy outcome

Immunity to heat shock proteins and pregnancy outcome

Infectious Diseases in Obstetrics and Gynecology 7(1-2): 35-38

Heat shock proteins are among the first proteins produced by the zygote after fertilization. In addition, the maternal decidua also expresses heat shock proteins during the early stages of pregnancy. Autoimmunity to heat shock proteins is not typically evident in healthy women of reproductive age. However, a chronic microbial infection, such as an asymptomatic Chlamydia trachomatis upper genital tract infection, results in prolonged exposure of the immune system to the microbial 60 kDa heat shock protein (hsp60). This may result in immunity to conserved hsp60 epitopes and subsequent autoimmunity to self hsp60. Women undergoing in vitro fertilization (IVF) who never realized they had a chlamydial infection but who were positive for cervical antichlamydial immunoglobulin A (IgA) antibodies had a much lower pregnancy rate than did women who were negative for these antibodies. Furthermore, cervical IgA antibodies to the chlamydial hsp60, as well as to a synthetic peptide corresponding to an hsp60 epitope present in both the chlamydial and human hsp60, also correlated with IVF failure. In vitro incubation of newly fertilized human embryos in medium containing maternal serum was shown to be deleterious to embryo development if the sera was positive for antibodies reactive with human hsp60. In another study, the ability of human hsp60 to elicit a lymphocyte proliferative response (cell-mediated immunity) correlated with a history of spontaneous early stage pregnancy loss. Thus, autoimmunity to hsp60 might increase susceptibility to early stage pregnancy loss.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 046330636

Download citation: RISBibTeXText

PMID: 10231007

Related references

On the model of feedback regulation of heat shock gene expression by heat shock proteins Demonstration of heat shock protein 70-containing complexes of unactivated heat shock transcription factor 1. Protein Engineering 8(Suppl. ): 35, 1995

Heat shock-induced dendritic cell maturation is coupled by transient aggregation of ubiquitinated proteins independently of heat shock factor 1 or inducible heat shock protein 70. Molecular Immunology 41(8): 785-792, 2004

Heat shock proteins in immunity. Handbook of Experimental Pharmacology 2006(172): 279-304, 2006

Heat shock proteins and immunity. Research in Immunology 140(7): 653-659, 1989

Distinct heat-shock element arrangements that mediate the heat shock, but not the late-embryogenesis induction of small heat-shock proteins, correlate with promoter activation in root-knot nematode feeding cells. Plant Molecular Biology 66(1-2): 151-164, 2008

A few considerations on the heat shock proteins in immunity. Romanian Journal of Internal Medicine 43(1-2): 35-47, 2005

Immunity to heat shock proteins and atherosclerosis. van Eden, W , Reprint Author Heat shock proteins and inflammation: 159-173, 2003

Heat shock proteins, immunity and glaucoma. Brain Research Bulletin 62(6): 473-480, 2004

Heat shock proteins and innate immunity. Clinical and Experimental Immunology 127(1): 1-3, 2002

Heat shock proteins: immunity and immunopathology. Immunology Today 11(7): 228-229, 1990

Heat-shock proteins: immunity and autoimmunity. Current Opinion in Immunology 4(4): 396-400, 1992

Immunity to heat shock proteins in rheumatoid arthritis. Clinical and Experimental Rheumatology 8(Suppl. 5): 69-74, 1990

The roles of heat shock proteins in tumor immunity. Cancer ChemoTherapy and Biological Response Modifiers 19: 371-383, 2001

Heat shock proteins as antigens in immunity against infection and self. Morimoto, R I, Tissieres, A, Georgopoulos, C Cold Spring Harbor Monograph Series; The biology of heat shock proteins and molecular chaperones 495-531, 1994

Immunity to heat shock proteins and arthritic disorders. Infectious Diseases in Obstetrics and Gynecology 7(1-2): 49-54, 1999