+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Immunoglobulin amyloidosis



Immunoglobulin amyloidosis



La Revue du Praticien 47(16): 1787-1791



AL amyloidosis is a rare disease. Its diagnosis is based on histopathology. It is always secondary to light chain, only rarely heavy chain, synthesis of monoclonal immunoglobulin, associated or not with tumoural proliferation (myeloma, Waldenström's macroglobulinaemia). Its pathophysiology has not been elucidated, but recent progress provided by biochemical and molecular biology studies has provided some data on the structural anomalies responsible for the formation of amyloid fibrils. As in AA amyloidosis, the clinical picture is heterogeneous and mainly depends on the degree and extent of the lesions. Prognosis remains poor and is influenced by the degree of cardiac, gastrointestinal, neurologic and renal involvement, but also by the presence of absence of underlying hemopathy, and particularly of myeloma. Treatment is still essentially symptomatic, but recent progress points to hope of effective treatment modalities aiming at reducing or eliminating the clone producing the immunoglobulin, or inhibiting the formation or amyloid fibrils.

(PDF emailed within 1 workday: $29.90)

Accession: 046333207

Download citation: RISBibTeXText

PMID: 9453204


Related references

Cardiac amyloidosis in African Americans: comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immunoglobulin light chain amyloidosis. American Heart Journal 158(4): 607-614, 2009

Frequency of hereditary systemic amyloidosis masquerading as immunoglobulin light chain, AL , amyloidosis. Journal of the American Society of Nephrology 13(Program and Abstracts Issue): 39A, 2002

AL amyloidosis with non-amyloid forming monoclonal immunoglobulin deposition; a case mimicking AHL amyloidosis. Bmc Nephrology 19(1): 337, 2018

Occurrence of prostaglandin D synthase in urine of patients with immunoglobulin light chain amyloidosis (Al amyloidosis). Prostaglandins 51(4): 291-0, 1996

Persistence of renal function in a patient diagnosed with concurrent amyloid amyloidosis and immunoglobulin light chain amyloidosis. Nihon Jinzo Gakkai Shi 58(5): 668-674, 2016

A first report of endoscopic ultrasound for the diagnosis of pancreatic amyloid deposition in immunoglobulin light chain (AL) amyloidosis (primary amyloidosis). Jop 14(3): 283-285, 2013

Clarifying immunoglobulin gene usage in systemic and localized immunoglobulin light-chain amyloidosis by mass spectrometry. Blood 129(3): 299-306, 2016

Successful treatment with i.v. immunoglobulin for localized cutaneous immunoglobulin light chain kappa-positive amyloidosis associated with dermatomyositis. Journal of Dermatology 45(5): E102-E103, 2017

Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18-22 April 2004. American Journal of Hematology 79(4): 319-328, 2005

High-Dose Melphalan and Stem Cell Transplantation in Patients on Dialysis Due to Immunoglobulin Light-Chain Amyloidosis and Monoclonal Immunoglobulin Deposition Disease. Biology of Blood and Marrow Transplantation 24(1): 127-132, 2017

Immunoglobulin anomaly : Advance in its diagnosis and treatment.4.Disease presenting immunoglobulin anomaly and its countermeasure.3.Amyloidosis. Nihon Naika Gakkai Zasshi 84(7): 1112-1116, 1995

Discordance between serum cardiac biomarker and immunoglobulin-free light-chain response in patients with immunoglobulin light-chain amyloidosis treated with immune modulatory drugs. American Journal of Hematology 85(10): 757-759, 2010

Useful polyclonal antibodies against synthetic peptides corresponding to immunoglobulin light chain constant region for immunohistochemical detection of immunoglobulin light chain amyloidosis. Pathology International 51(4): 264-270, 2001

Immunoglobulin M amyloidosis. Journal of Clinical Oncology 27(11): 1915-1916, 2009

Immunohistochemical study of immunoglobulin light chain amyloidosis with antibodies to the immunoglobulin light chain variable region. Pathology International 56(6): 324-330, 2006