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Immunoglobulin levels in breast secretions following prostaglandin F2 alpha-induced termination of pregnancy



Immunoglobulin levels in breast secretions following prostaglandin F2 alpha-induced termination of pregnancy



Ircs Journal of Medical Science 3: 92



This study was undertaken as a preliminary comparison of the immunoglobulin (Ig) content of milk secreted after prostaglandin F2 alpha or hypertonic saline-induced middle trimester abortion with that following spontaneous delivery prematurely and at term. In samples obtained from patients after midtrimester abortion, there was no obvious difference related to the method of inducing abortion, although there was an effect of the stage of lactation at which the sample was obtained. There was a significant progressive decline between Day 1 and 2 and Day 2 and 3 levels of IgA (P .005) and of IgG (P .02). Whereas there was no significant decrease in levels of IgM between Day 2 and 3, levels at Day 1 were significantly greater than levels at Day 2 (P .02) and Day 3 (P .005). A similar rapid decline in Ig levels of milk was observed after term delivery. Although the mean value for IgM after midtrimester abortion differed appreciably from that after term delivery, Ig levels of milk on the 1st day of lactation after midtrimester abortion did not differ significantly from those following spontaneous premature or term delivery. Within the midtrimester-induced abortion group, Ig levels were unrelated to gestational age, and within the spontaneous third trimester delivery group, there was no significant difference between premature and term deliveries. Therefore it appears that the Ig content of breast milk is more closely related to the stage of lactation than to the stage of gestation at, or method of, abortion or delivery.

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Accession: 046333287

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PMID: 12334865


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