+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Immunohistochemical demonstration of L-ornithine decarboxylase enzyme protein in different areas of the developing human brain



Immunohistochemical demonstration of L-ornithine decarboxylase enzyme protein in different areas of the developing human brain



Developmental Neuroscience 15(2): 87-93



L-Ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis and thus a unique marker of the proliferation and maturation processes, has been localized by means of immunohistochemistry in the human central nervous system. The enzyme protein has not only been found in the developing nervous system but also in the adult brain. The first immunopositive neuroblasts occurred in the 15th week of gravidity, whereas an increasing number of structures in the medulla oblongata and cerebellum showed ODC immunoreactivity in weeks 18-24 of gravidity. ODC immunoreactivity was revealed in multiple neurons and in the ependymal lining of ventricles. In the adult human brain ODC immunoreactivity was found in the hippocampus and in the spinal cord. In no case were immunoreactive glial cells observed.

(PDF emailed within 0-6 h: $19.90)

Accession: 046333880

Download citation: RISBibTeXText

PMID: 8168440

DOI: 10.1159/000111320


Related references

Immunohistochemical demonstration of ornithine decarboxylase in developing rat kidney. Acta Histochemica et Cytochemica 18(3): 337-342, 1985

Immunohistochemical localization of L-ornithine decarboxylase in developing rat brain. International Journal of Developmental Neuroscience 5(2): 145-150, 1987

Ornithine decarboxylase in developing brain of normal and hydrocephalic rats. Biochemical and immunohistochemical studies. Child's Nervous System 13(11-12): 578-583, 1998

Immunohistochemical demonstration of ornithine decarboxylase in tissues. A preliminary study. Acta Histochemica. Supplementband 33: 197-199, 1986

Expression of the genes coding for ornithine decarboxylase and its regulatory protein antizyme in the developing rat brain. Developmental Neuroscience 17(5-6): 286-291, 1995

Ornithine decarboxylase activity and polyamine concentrations in developing rat brain response to acute and chronic hypoxia and inhibition by l ornithine. Sutton, J R , G Coates And C S Houston (Ed ) Advances in The Biosciences, Vol 84 Hypoxia And Mountain Medicine; 7th International Hypoxia Symposium, Lake Louise, Alberta, Canada, February 1991 Xi+330p Pergamon Press: Oxford England, Uk; Elmsford, New York, Usa Illus 310, 1992

The inverse changes of mouse brain ornithine decarboxylase ec 4.1.1.17 and s adenosyl methionine decarboxylase ec 4.1.1.50 activities by chlorpromazine and imipramine dependence of ornithine decarboxylase induction on beta adrenoceptors. Biochemical Pharmacology 32(10): 1581-1586, 1983

Brain arginine decarboxylase, the biosynthetic enzyme for agmatine, is not ornithine decarboxylase. Society for Neuroscience Abstracts 25(1-2): 432, 1999

Cocaine exacerbates hypoxia-induced cell damage in the developing brain: effects on ornithine decarboxylase activity and protein synthesis. Biology of the Neonate 66(5): 254-266, 1994

Immunohistochemical localization of L-ornithine decarboxylase and its antizyme in rat brain. Molecular Biology of the Cell 3(SUPPL ): 358A, 1992

Immunohistochemical demonstration of ornithine decarboxylase expression in altered liver cell foci of rats treated with peroxisome proliferators. Journal of Toxicological Sciences 20(4): 517, 1995

Subcellular distribution of ornithine decarboxylase in rat liver and accessibility of the enzyme to alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase. Life Sciences 32(12): 1305-1312, 1983

Localization of ornithine decarboxylase in mutant cho cells that overproduce the enzyme differences between the intracellular distribution of monospecific ornithine decarboxylase antibodies and radiolabeled alpha difluoromethylornithine. European Journal of Cell Biology 35(2): 264-272, 1984