Improved liposome encapsulated hemoglobin by electret technology and its influence on the blood rheologic behavior in vitro
Deng, B.; Shi, X.; Deng, J.; Sun, C.; Wong, W.; Wang, Y.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 17(1): 29-32; 36
ISSN/ISBN: 1001-5515 PMID: 10879187 Accession: 046350864
To study the influence of different electret properties of Liposome Encapsulated Hemoglobin(LEH) on the blood rheologic behavior in vitro, four kinds of LEH have been prepared. Their electret properties have been determined by using Thermally Stimulated Depolarization Current(TSDC). The results show that 4# LEH, whose Ta is 12 degrees C and Ia is -5.6 x 10(-9) A, has the best electret property, furthermore, the results of the thrombus formation in vitro also show that the addition of 4# LEH induces the lightest thrombus figuration in vitro. It is obvious that the rational improvement of the electret property of LEH can meliorate the surface charge of blood and effectively inhibit the formation of thrombus.