+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Induction of a protective immune response to murine coronavirus with non-internal image anti-idiotypic antibodies



Induction of a protective immune response to murine coronavirus with non-internal image anti-idiotypic antibodies



Advances in Experimental Medicine and Biology 380: 165-172



Neurotropic murine coronaviruses (MHV) provide an excellent animal model to study experimental modulation of the immune response to a viral pathogen with anti-idiotypic antibodies. It is known that among the various types of anti-idiotypic antibodies (anti-Id), those designated beta (beta) or internal image can molecularly mimic the antigen and induce biological activities such as anti-viral protection and neutralization. We have recently shown that polyclonal non-internal image anti-idiotypic antibodies of the gamma-type could induce protective anti-coronavirus immunity. In the present study, a polyclonal anti-Id (Ab2) was induced against a neutralizing murine monoclonal antibody (MAb1), designated 5B170.11. Mice immunized with this affinity-purified rabbit Ab2 alpha, a non-internal image antibody, were partially protected against lethal infection by the JHM strain of MHV. However, other polyclonal and monoclonal non-internal image Ab2 induced against another neutralizing Mab1, designated 4-11G.6, were not able to protect mice against lethal infection with the A59 strain of MHV. These results demonstrate that anti-viral protection by altering the idiotypic network with non-internal image-bearing anti-idiotype reagents can be achieved even with some anti-Id of the alpha-type.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 046386215

Download citation: RISBibTeXText

PMID: 8830474


Related references

A conserved coronavirus epitope, critical in virus neutralization, mimicked by internal-image monoclonal anti-idiotypic antibodies. Journal of Virology 65(12): 6979-6984, 1991

The immune response to anti-idiotype antibodies bearing an internal image epitope of tetanus toxin/toxoid. I. Induction of the humoral immune response. International Archives of Allergy and Applied Immunology 95(2-3): 109-121, 1991

The immune response to anti-idiotype antibodies bearing an internal image epitope of tetanus toxin/toxoid. II. Comparison of the primary humoral immune response to xenogeneic Ab2 beta 1 and Ab2 beta 2 internal image anti-idiotype antibodies. International Archives of Allergy and Applied Immunology 95(2-3): 122-127, 1991

Induction of immune responses with anti-idiotypic antibodies: implications for the induction of protective immunity. Springer Seminars in Immunopathology 6(1): 79-97, 1983

Further characterization of internal image-bearing anti-idiotypic antibodies: specific binding to immunoglobulin receptors on murine hybridoma cells secreting antibodies to hepatitis B surface antigen. Scandinavian Journal of Immunology 23(4): 481-489, 1986

Generation of internal image monoclonal anti-idiotypic antibodies against idiotypic antibodies to GP5 antigen of porcine reproductive and respiratory syndrome virus. Journal of Virological Methods 149(2): 300-308, 2008

Induction of an anti-hepatitis B surface antigen response in mice by noninternal image (Ab2 alpha) anti-idiotypic antibodies. Journal of Immunology 138(10): 3419-3425, 1987

Angiotensin II (AII)-related idiotypic network. I. Common occurrence of AII internal image on rabbit anti-idiotypic antibodies. Journal of Immunology 140(9): 3052-3058, 1988

Induction of immune response to bovine herpesvirus-1 with anti-idiotypic antibodies. Viral Immunology 4(2): 111-122, 1991

Induction of immune response to influenza virus with anti-idiotypic antibodies. Journal of Virology 63(6): 2758-2767, 1989

Characterization of & induction of immune response to anti-idiotypic antibodies for JE virus. Indian Journal of Medical Research Section A, Infectious Diseases 93(May): 131-139, 1991

Characterization of and induction of immune response to anti idiotypic antibodies for je virus. Indian Journal of Medical Research Section A 93(MAY): 131-139, 1991

Vaccination against coronavirus infection in different strains of mice by non-internal image anti-idiotypic antibody. 9TH INTERNATIONAL CONGRESS OF IMMUNOLOGY [Author] The 9th International Congress of Immunology : 177, 1995

The induction of an immune response to influenza virus antigens by anti-idiotypic antibodies. Zhurnal Mikrobiologii Epidemiologii i Immunobiologii .(1): 40-44, 1995