+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Insights into oxidative stress and atherosclerosis



Insights into oxidative stress and atherosclerosis



Canadian Journal of Cardiology 16 Suppl D: 2d-4d



Compelling evidence points to oxidative stress as an important trigger in the complex chain of events leading to atherosclerosis. Randomized clinical trials have not provided definitive evidence of the beneficial effect of antioxidant vitamins. Problems associated with the use of vitamins include their potential pro-oxidant effects and the decreased absorption of natural gamma-tocopherol caused by alpha-tocopherol supplements. Probucol and amlodipine are more powerful lipophilic antioxidants than vitamin E. They also do not appear to have significant pro-oxidant properties. Probucol has been shown to prevent coronary restenosis after balloon angioplasty in clinical trials. Its high density lipoprotein-lowering effect, however, prevents it from being protective against progression of coronary atherosclerosis. Slowing or reversing the atherosclerotic process with an antioxidant likely requires the use of a powerful lipophilic antioxidant that has neutral or positive effects on serum lipids when given alone or in combination with a lipid-lowering agent.

(PDF emailed within 1 workday: $29.90)

Accession: 046420254

Download citation: RISBibTeXText

PMID: 10932028


Related references

New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis. Redox Biology 20: 247-260, 2018

Oxidative stress: New insights on the association of non-alcoholic fatty liver disease and atherosclerosis. World Journal of Hepatology 7(10): 1325-1336, 2015

Novel Insights in the Metabolic Syndrome-induced Oxidative Stress and Inflammation-mediated Atherosclerosis. Current Cardiology Reviews 14(1): 4-14, 2017

Serotonin in peripheral blood reflects oxidative stress and plays a crucial role in atherosclerosis: Novel insights toward holistic anti-atherothrombotic strategy. Atherosclerosis 246: 157-160, 2016

Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation. Antioxidants 8(3), 2019

Oxidative Stress in Atherosclerosis Development The Central Role of LDL and Oxidative Burst. Endocrine Metabolic & Immune Disorders - Drug Targets 12(4): 351-360, 2012

Oxidative stress in atherosclerosis development: the central role of LDL and oxidative burst. Endocrine, Metabolic and Immune Disorders Drug Targets 12(4): 351-360, 2013

Good stress, bad stress and oxidative stress: insights from anticipatory cortisol reactivity. Psychoneuroendocrinology 38(9): 1698-1708, 2014

Does oxidative DNA damage cause atherosclerosis and metabolic syndrome?: new insights into which came first: the chicken or the egg. Circulation Research 107(8): 940-942, 2010

Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice. Lipids in Health and Disease 17(1): 220, 2018

Crystal structure of peroxide stress regulator from Streptococcus pyogenes provides functional insights into the mechanism of oxidative stress sensing. Journal of Biological Chemistry 288(25): 18311-18324, 2013

Oxidative stress and atherosclerosis. Orvosi Hetilap 156(28): 1115-1119, 2015

Oxidative Stress in Atherosclerosis. Current Atherosclerosis Reports 19(11): 42, 2018

Oxidative stress and atherosclerosis. Pathophysiology 13(3): 129-142, 2006

Oxidative stress in atherosclerosis. Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 107(3): 502-511, 2004