+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Interaction of perirhinal cortex with the fornix-fimbria: memory for objects and "object-in-place" memory



Interaction of perirhinal cortex with the fornix-fimbria: memory for objects and "object-in-place" memory



Journal of Neuroscience 16(18): 5864-5869



Four monkeys (Macaca mulatta) were trained preoperatively in an automated object-in-place memory task in which they learned 20 new scenes in each daily session. In the object-in-place memory task, the correct, rewarded response in each scene is to a particular object of a pair, which always occupies a particular position in a unique background that has been generated using randomly chosen colors and shapes. Each animal then underwent two surgeries, with a period of testing after each. In the first, control surgery, each animal had either a unilateral lesion of the perirhinal cortex or unilateral fornixfimbria transection, combined with section of the body and splenium of the corpus callosum and the anterior commissure (to prevent interhemispheric transfer of visual information). The disconnection was completed in the second surgery, after which all animals had a unilateral perirhinal cortex ablation in one hemisphere, unilateral fornix-fimbria transection in the contralateral hemisphere, and partial forebrain commissurotomy. The monkeys performance was compared for the learning of 200 scenes, preoperatively and after each surgery. After control surgery, the animals were mildly impaired on the object-in-place task. After disconnection, the animals showed a severe impairment in object-in-place memory. We conclude from this that, in episodic memory, the perirhinal cortex provides input of visual object information to the subiculum, hippocampus, and fornix.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 046430469

Download citation: RISBibTeXText

PMID: 8795638


Related references

Interaction of Perirhinal Cortex with the FornixFimbria: Memory for Objects and Object-in-Place Memory. The Journal of Neuroscience 16(18): 5864-5869, 1996

Lesions of rat perirhinal cortex exacerbate the memory deficit observed following damage to the fimbria-fornix. Behavioral Neuroscience 109(4): 620-630, 1995

The roles of perirhinal cortex, postrhinal cortex, and the fornix in memory for objects, contexts, and events in the rat. Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology 58(3-4): 202-217, 2005

Functionally dissociating aspects of event memory: the effects of combined perirhinal and postrhinal cortex lesions on object and place memory in the rat. Journal of Neuroscience 19(1): 495-502, 1999

Functionally dissociation aspects of event memory: the effects of combined perirhinal and postrhinal cortex lesions on object and place memory in the rat. Journal of Neuroscience ): 5-502, 1999

Functionally Dissociating Aspects of Event Memory: the Effects of Combined Perirhinal and Postrhinal Cortex Lesions on Object and Place Memory in the Rat. The Journal of Neuroscience 19(1): 495-502, 1999

The effects of neurotoxic lesions of the perirhinal cortex combined to fornix transection on object recognition memory in the rat. Behavioural Brain Research 88(2): 181-193, 1997

Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex. Journal of Neuroscience 27(11): 2948-2957, 2007

Dissociable involvement of estrogen receptors in perirhinal cortex-mediated object-place memory in male rats. Psychoneuroendocrinology 107: 98, 2019

Why does brain damage impair memory? A connectionist model of object recognition memory in perirhinal cortex. Journal of Neuroscience 26(47): 12186-12197, 2006

Memory for spatial location and object-place associations are differently processed by the hippocampal formation, parahippocampal areas TH/TF and perirhinal cortex. Hippocampus 18(1): 64-80, 2008

Concurrent assessment of memory for object and place: Evidence for different preferential importance of perirhinal cortex and hippocampus and for promnestic effect of a neurokinin-3 R agonist. Neurobiology of Learning and Memory 130: 149-158, 2016

Hippocampus, fimbria-fornix, amygdala, and memory: object discriminations in rats. Behavioral Neuroscience 106(5): 751-761, 1992

Interaction between perirhinal and medial prefrontal cortex is required for temporal order but not recognition memory for objects in rats. Journal of Neuroscience 24(19): 4596-4604, 2004

Place learning and object recognition by rats subjected to transection of the fimbria-fornix and/or ablation of the prefrontal cortex. Brain Research Bulletin 63(3): 217-236, 2004