+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis



Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis



Osteoarthritis and Cartilage 3(4): 269-273



The aim of this study was to determine the comparative efficacy and safety of intra-articular (i/a) triamcinolone. hexacetonide (TH) and i/a hyaluronic acid (HA) in inflammatory knee osteoarthritis. A randomized double-blind comparative trail was carried out in a rheumatology outpatient department. There were 63 patients (24 male, 39 female, mean age 70.5 years) with bilateral symptomatic knee osteoarthritis with effusion. Each was given five HA injections at weekly intervals; or 20 mg TH followed by four placebo (saline) injections. Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months. Assessment included recording of: visual analog scores (VAS) for pain; duration of stiffness; range of movement; joint effusion; local heat; synovial thickening; joint-line and periarticular tenderness. The principal outcome measure was pain on a self-selected activity assessed by Vas. The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period. However, there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups. In patients remaining in the study, significantly less pain was experienced by the HA group during the 6 month follow-up period. Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period. Other parameters showed a similar trend in favor of HA. We could not, however, demonstrate significant differences between the placebo and active treatments. HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 046448212

Download citation: RISBibTeXText

PMID: 8689462

DOI: 10.1016/s1063-4584(05)80018-4


Related references

A double-blind trial of intra-articular hyaluronic acid versus intra-articular triamcinolone hexacetonide in knee osteoarthritis. Arthritis and Rheumatism 35(9 Suppl. ): S132, 1992

Pain reduction and improvement of function following ultrasound-guided intra-articular injections of triamcinolone hexacetonide and hyaluronic acid in hip osteoarthritis. Journal of Biological Regulators and Homeostatic Agents 30(4 Suppl 1): 51-62, 2016

Efficacy and Tolerability of Hylan G-F 20 Compared to Intra-articular Triamcinolone Hexacetonide in Patients with Osteoarthritis of the Knee in a Randomized, Evaluator-Blinded Study (SS-38). Arthroscopy: Journal of Arthroscopic and Related Surgery 19(5-Supp-S): 65-66, 2003

Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis. Clinical Rheumatology 37(5): 1341-1350, 2018

Intra-articular triamcinolone hexacetonide in knee osteoarthritis: Factors influencing the clinical response. Annals of the Rheumatic Diseases 54(5): 378-381, 1995

Intra-articular steroids in knee osteoarthritis: a comparative study of triamcinolone hexacetonide and methylprednisolone acetate. Clinical Rheumatology 23(2): 116-120, 2004

Intra-articular triamcinolone hexacetonide and osmic acid in persistent synovitis of the knee. Scandinavian Journal of Rheumatology 4(3): 125-128, 1975

Combined intra-articular injection of corticosteroid and hyaluronic acid reduces pain compared to hyaluronic acid alone in the treatment of knee osteoarthritis. Knee Surgery Sports Traumatology Arthroscopy 27(6): 1974-1983, 2019

Comparison of intra-articular methotrexate with intra-articular triamcinolone hexacetonide by thermography. Current Medical Research and Opinion 5(2): 141-146, 1977

Intra-Articular, Single-Shot Hylan G-F 20 Hyaluronic Acid Injection Compared with Corticosteroid in Knee Osteoarthritis: A Double-Blind, Randomized Controlled Trial. Journal of Bone and Joint Surgery. American Volume 98(11): 885-892, 2016

Intra-articular hyaluronic acid for osteoarthritis of the knee. Technology Evaluation Center Assessment Program. Executive Summary 29(6): 1-3, 2015

Injection of the rheumatoid knee: does intra-articular methotrexate or rifampicin add to the benefits of triamcinolone hexacetonide?. British Journal of Rheumatology 37(7): 770-772, 1998

Intra-articular hyaluronic acid (viscosupplementation) for knee osteoarthritis. Issues in Emerging Health Technologies 2006(94): 1-4, 2006

Intra-articular hyaluronic acid injections for knee osteoarthritis. American Family Physician 62(3): 565, 2000

Intra-articular hyaluronic acid for treatment of osteoarthritis of the knee. JAMA 291(12): 1440-1; Author Reply 1441-2, 2004