+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Intrahepatic cholestasis of pregnancy has no effect on maternal serum second trimester alpha-fetoprotein and hCG



Intrahepatic cholestasis of pregnancy has no effect on maternal serum second trimester alpha-fetoprotein and hCG



Acta Obstetricia et Gynecologica Scandinavica 79(7): 548-552



To investigate the association between intrahepatic cholestasis and Down's syndrome screening analytes (alpha-fetoprotein [AFP] and hCG) during the second trimester. Measurements of maternal serum AFP and hCG concentrations were retrospectively analyzed in relation to intrahepatic cholestasis in a cohort of 33 consecutive singleton pregnancies affected by cholestasis from January 1995 through December 1997 at the University Hospital of Kuopio, and then compared with those in healthy singleton control pregnancies (n=5680) from the same clinic over the same period of time. Geometric means of maternal serum AFP and hCG concentrations in pregnancies affected by cholestasis were 1.12 and 0.98 multiples of the median [MoM], respectively. Mean maternal age was significantly higher in the subjects than in controls (30.6 years compared with 28.8 years). In relation to Down's syndrome risk assessment, the pattern of the two markers together with maternal age indicated high risk as often in the study subjects as in the controls. Median serum AFP and hCG concentrations in pregnancies complicated by intrahepatic cholestasis were not significantly different from those in unaffected pregnancies. There is no need to take the hepatic disorder into account in maternal serum screening.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 046452155

Download citation: RISBibTeXText

PMID: 10929953

DOI: 10.1034/j.1600-0412.2000.079007548.x


Related references

Does unexplained second-trimester (15 to 20 weeks' gestation) maternal serum alpha-fetoprotein elevation presage adverse perinatal outcome? Pitfalls and preliminary studies with late second- and third-trimester maternal serum alpha-fetoprotein. American Journal of Obstetrics and Gynecology 164(3): 829-836, 1991

First trimester maternal serum PAPP-A levels and associated pregnancy complications in intrahepatic cholestasis of pregnancy. Clinical and Experimental Obstetrics and Gynecology 43(5): 673-677, 2016

The effect of maternal weight on the serum alpha fetoprotein concentration during the second trimester of pregnancy. Clinical Genetics 28(5): 473, 1985

Second-trimester maternal serum marker screening: maternal serum alpha-fetoprotein, beta-human chorionic gonadotropin, estriol, and their various combinations as predictors of pregnancy outcome. American Journal of Obstetrics and Gynecology 181(4): 968-974, 1999

The effect of fetomaternal bleeding on the risk of adverse pregnancy outcome in patients with elevated second-trimester maternal serum alpha-fetoprotein levels. American Journal of Obstetrics and Gynecology 171(2): 315-9; Discussion 319-20, 1994

Reference values for maternal serum alpha-fetoprotein in the second trimester of pregnancy. Ugeskrift for Laeger 148(1): 6-8, 1985

Maternal serum alpha-fetoprotein levels during second trimester termination of pregnancy. Journal of Obstetrics & Gynaecology 1(3): 159-161, 1981

Elevated maternal serum alpha-fetoprotein, second-trimester oligohydramnios, and pregnancy outcome. Obstetrics and Gynecology 62(3): 301-304, 1983

Second-trimester maternal serum alpha-fetoprotein and risk of adverse pregnancy outcome. Obstetrics & Gynecology 97(2): 277-282, 2001

Fetal sex-related differences in maternal serum alpha-fetoprotein during the second trimester of pregnancy. American Journal of Obstetrics and Gynecology 146(7): 786-789, 1983

Smoking habits and maternal serum alpha-fetoprotein levels during the second trimester of pregnancy. British Journal of Obstetrics and Gynaecology 90(8): 716-717, 1983

Local norms of maternal serum alpha fetoprotein values in early second trimester a prelude to a down's syndrome screening program incorporating maternal serum alpha fetoprotein values. SMJ Singapore Medical Journal 32(2): 134-137, 1991

Chronic cholestasis of infancy The significance of progressive familial intrahepatic cholestasis and prognostic implications of serum alpha-fetoprotein. JPGN 31(Suppl. 2): S109, 2000

Elevated second trimester maternal serum alpha fetoprotein is more predictive of certain pregnancy complications than elevated third trimester MSAFP A cohort study. American Journal of Human Genetics 51(4 Suppl. ): A19, 1992

High maternal serum alpha-fetoprotein levels during the 2nd trimester of pregnancy: diagnostic approach. Journal of Nuclear Medicine and Allied Sciences 33(3 Suppl): 81-84, 1989