+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Amyloid and the origin of life: self-replicating catalytic amyloids as prebiotic informational and protometabolic entities

Amyloid and the origin of life: self-replicating catalytic amyloids as prebiotic informational and protometabolic entities

Cellular and Molecular Life Sciences 75(9): 1499-1507

A crucial stage in the origin of life was the emergence of the first molecular entity that was able to replicate, transmit information, and evolve on the early Earth. The amyloid world hypothesis posits that in the pre-RNA era, information processing was based on catalytic amyloids. The self-assembly of short peptides into β-sheet amyloid conformers leads to extraordinary structural stability and novel multifunctionality that cannot be achieved by the corresponding nonaggregated peptides. The new functions include self-replication, catalytic activities, and information transfer. The environmentally sensitive template-assisted replication cycles generate a variety of amyloid polymorphs on which evolutive forces can act, and the fibrillar assemblies can serve as scaffolds for the amyloids themselves and for ribonucleotides proteins and lipids. The role of amyloid in the putative transition process from an amyloid world to an amyloid-RNA-protein world is not limited to scaffolding and protection: the interactions between amyloid, RNA, and protein are both complex and cooperative, and the amyloid assemblages can function as protometabolic entities catalyzing the formation of simple metabolite precursors. The emergence of a pristine amyloid-based in-put sensitive, chiroselective, and error correcting information-processing system, and the evolvement of mutualistic networks were, arguably, of essential importance in the dynamic processes that led to increased complexity, organization, compartmentalization, and, eventually, the origin of life.

(PDF emailed within 0-6 h: $19.90)

Accession: 046508419

Download citation: RISBibTeXText

PMID: 29550973

DOI: 10.1007/s00018-018-2797-9

Related references

Self-Propagating -Sheet Polypeptide Structures as Prebiotic Informational Molecular Entities The Amyloid World. Origins of Life and Evolution of Biospheres 39(2): 141-150, 2009

Self-propagating beta-sheet polypeptide structures as prebiotic informational molecular entities: the amyloid world. Origins of Life and Evolution of the Biosphere 39(2): 141-150, 2009

Towards Prebiotic Catalytic Amyloids Using High Throughput Screening. Plos One 10(12): E0143948, 2017

Origin of life. Primordial genetics: Information transfer in a pre-RNA world based on self-replicating beta-sheet amyloid conformers. Journal of Theoretical Biology 382: 292-297, 2016

Peptide Amyloids in the Origin of Life. Journal of Molecular Biology 430(20): 3735-3750, 2018

Kinetic origin of heredity in a replicating system with a catalytic network. Journal of Biological Physics 28(4): 781-792, 2002

On a kinetic origin of heredity: minority control in a replicating system with mutually catalytic molecules. Journal of Theoretical Biology 214(4): 563-576, 2002

ORIGIN OF LIFE. Beyond prebiotic chemistry. Science 352(6290): 1174-1175, 2016

Life origin; prebiotic phase. Vestnik Rossiyskoy Akademii Nauk: 1, Pages 976-983. 2002., 2002

Origin of life. II. From prebiotic replicators to protocells. Archives des Sciences et Compte Rendu des Seances de la Societe 52(2): 101-109, 2003

Prebiotic organic syntheses and the origin of life. Pages 53-92 1983, 1983

The origin of life. A cybernetic and informational process. Acta Biotheoretica 28(1): 19-47, 1979

Taming Prebiotic Chemistry: The Role of Heterogeneous and Interfacial Catalysis in the Emergence of a Prebiotic Catalytic/Information Polymer System. Life 6(4), 2016

Compositional complementarity and prebiotic ecology in the origin of life. Bioessays 28(4): 399-412, 2006

The origin of life: Self-replicating asymmetrical frozen probability. Medical Hypotheses 50(1): 81-83, 1998