+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Langerhans cell migration in murine cutaneous leishmaniasis: regulation by tumor necrosis factor alpha, interleukin-1 beta, and macrophage inflammatory protein-1 alpha



Langerhans cell migration in murine cutaneous leishmaniasis: regulation by tumor necrosis factor alpha, interleukin-1 beta, and macrophage inflammatory protein-1 alpha



Developmental Immunology 6(1-2): 3-11



After intradermal infection of mice with the obligatory intracellular parasite Leishmania major, Langerhans cells (LC) are intimately involved in the induction of the primary T-cell immune response. LC can phagocytose Leishmania and transport ingested parasites from the infected skin to the regional lymph nodes. Since TNF alpha and IL-1 beta have been shown to induce LC migration after epicutaneous exposure to skin-sensitizing chemicals, we investigated the involvement of both cytokines in the migration of Leishmania-infected LC. In addition, the relevance of two chemokines of the beta subfamily, macrophage inflammatory protein 1 alpha (MIP-1 alpha) and macrophage chemoattractant protein 1 (MCP-1), was analyzed. In vivo depletion of TNF alpha significantly reduced the amount of infected LC and the parasite load in the draining lymph nodes. Administration of recombinant TNF alpha caused the reverse effect. In contrast, the depletion of IL-1 beta enhanced the parasite-induced LC migration, whereas treatment with recombinant IL-1 beta, as well as recombinant MIP-1 alpha, reduced the rate of infected LC in the lymph nodes. MCP-1 did not influence LC migration. Our data demonstrate that TNF alpha and IL-1 beta are regulating the LC-mediated transport of Leishmania and also provide evidence for the involvement of macrophage attractant chemokines in this process.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 046516703

Download citation: RISBibTeXText

PMID: 9716900


Related references

Langerhans Cell Migration in Murine Cutaneous Leishmaniasis: Regulation by Tumor Necrosis Factor Interleukin-1 , and Macrophage Inflammatory Protein-1. Developmental Immunology 6(1-2): 3-11, 1998

Contribution of tumor necrosis factor alpha and interleukin-1 alpha on the production of macrophage inflammatory protein-2 in response to respiratory syncytial virus infection in a murine macrophage cell line, RAW264.7. Journal of Medical Virology 53(2): 145-149, 1997

Dynamics and regulation of macrophage tumor necrosis factor alpha tnf interleukin 1 alpha il 1 alpha and interleukin 1 beta il 1 beta gene expression by arachidonate metabolites. Powanda, M C , Et Al (Ed ) Progress in Leukocyte Biology, Vol 8 Monokines And Other Non-Lymphocytic Cytokines; International Workshop, Hilton Head Island, South Carolina, Usa, December 6-10, 1987 Xxix+414p Alan R Liss, Inc : New York, New York, Usa Illus 61-66, 1988

Influence of tumor necrosis factor- alpha and interleukin-1 beta on Langerhans 39; cell migration in patients with psoriasis. FASEB Journal 18(4-5): Abst 771 8, 2004

Treatment of BCL-1 murine B-cell leukemia with recombinant cytokines. Comparative analysis of the anti-leukemic potential of interleukin 1 beta (IL-1 beta), interleukin 2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF alpha), granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF), and their combination. Leukemia and Lymphoma 7(1-2): 79-86, 1992

Treatment of bcl 1 murine b cell leukemia with recombinant cytokines comparative analysis of the anti leukemic potential of interleukin 1 beta il 1 beta interleukin 2 il 2 interleukin 6 il 6 tumor necrosis factor alpha tnfalpha granulocyte colony stimulant factor g csf granulocyte macrophage colony stimulating factor gm csf and their combination. Leukemia and Lymphoma 7(1-2): 79-86, 1992

Cytokine expression by neutrophils and macrophages in vivo: endotoxin induces tumor necrosis factor-alpha, macrophage inflammatory protein-2, interleukin-1 beta, and interleukin-6 but not RANTES or transforming growth factor-beta 1 mRNA expression in acute lung inflammation. American Journal of Respiratory Cell and Molecular Biology 10(2): 148-153, 1994

Cutaneous trauma, tumor necrosis factor-alpha and Langerhans cell migration. British Journal of Dermatology 129(4): 479, 1993

Regulation of Langerhans cell protein antigen presentation by calcitonin gene-related peptide , granulocyte-macrophage colony stimulating factor and tumor necrosis factor-alpha. Journal of Investigative Dermatology 100(4): 489, 1993

Cytokine gene expression in murine epidermal cell suspensions: interleukin 1 beta and macrophage inflammatory protein 1 alpha are selectively expressed in Langerhans cells but are differentially regulated in culture. Journal of Experimental Medicine 176(4): 1221-1226, 1992

Interleukin-1 induction of tumor necrosis factor-alpha mRNA and bioactive tumor necrosis factor-alpha in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis. Biochemical and Biophysical Research Communications 194(1): 163-169, 1993

Regulation of murine protein C gene expression in vivo: effects of tumor necrosis factor-alpha, interleukin-1, and transforming growth factor-beta. Thrombosis and Haemostasis 82(4): 1297-1301, 1999

Tumor necrosis factor-alpha (TNF-alpha) potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem cell factor and interleukin-7: novel stimulatory role of p55 TNF receptors. Blood 84(5): 1528-1533, 1994

Stimulation of Langerhans cell migration in mice by tumour necrosis factor alpha and interleukin 1 beta. Advances in Experimental Medicine and Biology 417: 121-124, 1997

Contribution of interleukin-1-beta to tumour necrosis factor-alpha induced Langerhans cell migration. British Journal of Dermatology 134(3): 567, 1996