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Long-range correlations in genomic DNA: a signature of the nucleosomal structure

Long-range correlations in genomic DNA: a signature of the nucleosomal structure

Physical Review Letters 86(11): 2471-2474

We use the "wavelet transform microscope" to carry out a comparative statistical analysis of DNA bending profiles and of the corresponding DNA texts. In the three kingdoms, one reveals on both signals a characteristic scale of 100-200 bp that separates two different regimes of power-law correlations (PLC). In the small-scale regime, PLC are observed in eukaryotic, in double-strand DNA viral, and in archaeal genomes, which contrasts with their total absence in the genomes of eubacteria and their viruses. This strongly suggests that small-scale PLC are related to the mechanisms underlying the wrapping of DNA in the nucleosomal structure. We further speculate that the large scale PLC are the signature of the higher-order structure and dynamics of chromatin.

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Accession: 046567069

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PMID: 11289957

DOI: 10.1103/PhysRevLett.86.2471

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