+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Long-term administration of Sopungsungi-won (SP) prevents diabetic nephropathy in Zucker diabetic fatty rats



Long-term administration of Sopungsungi-won (SP) prevents diabetic nephropathy in Zucker diabetic fatty rats



Archives of Pharmacal Research 25(6): 917-922



We investigated the long term effects of Sopungsungi-won (SP), a Korean traditional formula used for senile constipation and diabetes mellitus, on the development of diabetic nephropathy (DN) in Zucker diabetic fatty (ZDF) rats. ZDF rats were fed regular laboratory chow mixed with SP or rosiglitazone (RSG) for an 8-week period. Kidney hypertrophy was developed with increasing plasma glucose level, and glomerular hypertrophy was improved by 22% and 45% in SP- and RSG-treated rats, respectively. Urinary glucose and albumin excretions were also significantly lower in SP-treated rats than in ZDF control rats. Activation of the mitogen-activated protein kinase (MAPK)-transforming growth factor beta1 (TGF beta1)-fibronectin pathway in kidney, responsible for glomerular dysfunction, was markedly blunted by SP treatment in a dose dependent manner. Our findings, for the first time, provide strong evidence that long-term administration of SP formula prevents the development and progression of DN in ZDF rats. Human trials are needed to confirm these experimental results.

(PDF emailed within 1 workday: $29.90)

Accession: 046567401

Download citation: RISBibTeXText

PMID: 12510848


Related references

Sopungsungi-won (SP) prevents the onset of hyperglycemia and hyperlipidemia in Zucker diabetic fatty rats. Archives of Pharmacal Research 25(6): 923-931, 2003

Vasopeptidase inhibition prevents nephropathy in Zucker diabetic fatty rats. Cardiovascular Research 60(2): 447-454, 2003

LR-90 prevents dyslipidaemia and diabetic nephropathy in the Zucker diabetic fatty rat. Diabetologia 51(5): 882-891, 2008

Rice endosperm protein slows progression of fatty liver and diabetic nephropathy in Zucker diabetic fatty rats. British Journal of Nutrition 116(8): 1326-1335, 2016

KIOM-79, an Inhibitor of AGEs-Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats. Evidence-Based Complementary and Alternative Medicine 2011: 761859, 2009

Angiotensin-(1-7) attenuates diabetic nephropathy in Zucker diabetic fatty rats. American Journal of Physiology. Renal Physiology 302(12): F1606-F1615, 2012

Urinary cystatin C as a biomarker for diabetic nephropathy and its immunohistochemical localization in kidney in Zucker diabetic fatty (ZDF) rats. Experimental and Toxicologic Pathology 65(5): 615-622, 2014

Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats. American Journal of Physiology. Renal Physiology 307(10): F1123-F1131, 2015

The effect of long term exercise training on microvascular risk factors associated with diabetic nephropathy in the obese diabetic zucker rat. Clinical Chemistry 37(6): 1066, 1991

The heme oxygenase system suppresses perirenal visceral adiposity, abates renal inflammation and ameliorates diabetic nephropathy in Zucker diabetic fatty rats. Plos One 9(1): E87936, 2014

Chronic oral administration of bis oxovanadium a protein tyrosine phosphatase inhibitor prevents the onset of diabetes in Zucker diabetic fatty rats. FASEB Journal 17(4-5): Abstract No 374 8, 2003

Differences in plasma homocysteine levels between Zucker fatty and Zucker diabetic fatty rats following 3 weeks oral administration of organic vanadium compounds. Journal of Trace Elements in Medicine and Biology 19(4): 251-258, 2006

Long-term treatment with nebivolol attenuates renal damage in Zucker diabetic fatty rats. Journal of Hypertension 29(8): 1613-1623, 2012

Differential adipose tissue inflammatory state in obese nondiabetic Zucker fatty rats compared to obese diabetic zucker diabetic fatty rats. Hormone and Metabolic Research 44(4): 273-278, 2012

A low-protein diet exerts a beneficial effect on diabetic status and prevents diabetic nephropathy in Wistar fatty rats, an animal model of type 2 diabetes and obesity. Nutrition and Metabolism 15: 20, 2018