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Long-term effects of nasal continuous positive airway pressure on pulmonary function and blood gas data in patients with obstructive sleep apnea syndrome



Long-term effects of nasal continuous positive airway pressure on pulmonary function and blood gas data in patients with obstructive sleep apnea syndrome



Nihon Kokyuki Gakkai Zasshi 36(12): 1011-1016



To evaluate the long-term effects of nasal continuous positive airway pressure (NCPAP) on pulmonary function and blood gas levels in patients with obstructive sleep apnea syndrome (OSAS), we examined the pulmonary functions and blood gases in 25 male patients with OSAS before and after NCPAP treatment. After 22 months of treatment (titration: 13 cm H2O), no significant changes were observed in the patients' spirograms, pulmonary gas volumes, or diffusion capacity. However, PaO2 levels increased significantly (p < 0.01), from 73.8 mmHg to 79.5 mmHg; PaCO2 levels decreased significantly (p < 0.05), from 45.6 mmHg to 44.2 mmHg; and A-aDO2 levels also decreased significantly (p < 0.05), from 18.7 mmHg to 15.0 mmHg. The patients were divided into a hypoventilated group (PaCO2 > 45 mmHg; 11 cases) and normoventilated group (PaCO2 < or = 45 mmHg; 14 cases). After NCPAP treatment, increased PaO2 and decreased PaCO2 levels were observed in the hypoventilated group, and increased PaO2 and decreased A-aDO2 levels were observed in the normoventilated group. These results suggest that long-term NCPAP treatment improves gas exchange in OSAS patients without influencing the results of pulmonary function tests.

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Accession: 046568841

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PMID: 10064953


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