EurekaMag
+ Translate
+ Most Popular
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
Observations on the Umaria marine bed
10 years of hearing conservation in the Royal Air Force
Chocolate crumb - dairy ingredient for milk chocolate
Effect of daily gelatin ingestion on human scalp hair
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
The composition of pampas-grass (Cortaderia argentea.)
The Accraian Series:
The mechanism of the Liebermann-Burchard reaction of sterols and triterpenes and their esters
Cerebrovascular Doppler ultrasound studies (cv-Doppler)
Toria: PT-303 - first national variety
Hair growth promoting activity of tridax procumbens
Productivity of Pekin x Khaki Campbell ducks
A stable cytosolic expression of VH antibody fragment directed against PVY NIa protein in transgenic potato plant confers partial protection against the virus
Solar treatment of wheat loose smut
Swimmers itch in the Lake of Garda
Bactofugation and the Bactotherm process
The effects of prefrontal lobotomy on aggressive behavior in dogs
Visual rating scales for screening whorl-stage corn for resistance to fall armyworm
Breakdown of seamounts at the trench axis, viewed from gravity anomaly
Kooken; pennsylvania's toughest cave
Recovery of new dinosaur and other fossils from the Early Cretaceous Arundel Clay facies (Potomac Group) of central Maryland, U.S.A
Zubor horny (Bison bonasus) v prirodnych podmienkach Slovensku
The extended Widal test in the diagnosis of fevers due to Salmonella infection
Hair of the american mastodon indicates an adaptation to a semi aquatic habitat

Longitudinal humoral immune responses of Indian leaf monkey (Presbytis entellus) to Brugia malayi infection


Longitudinal humoral immune responses of Indian leaf monkey (Presbytis entellus) to Brugia malayi infection



Parasitology 119: 53-60



ISSN/ISBN: 0031-1820

PMID: 10446704

DOI: 10.1017/s0031182099004394

Humoral immune responses of the Indian leaf monkey (Presbytis entellus) experimentally infected with Brugia malayi and exhibiting disease manifestations were studied. Microfilaraemia, filaria-specific IgG and circulating immune complexes (CICs) were determined in the monkeys at different time-points after inoculation of B. malayi 3rd-stage larvae. Sera were analysed for recognition pattern of adult parasite antigen molecules by immunoblotting. More than 60% of the infected monkeys developed episodic or persistent limb oedema with or without fever and with low or no microfilaraemia. While both CIC and filaria specific IgG levels were comparable in animals showing no disease symptoms (asymptomatics) and some animals showing symptoms (symptomatics), IgG levels peaked during pre-patent stage in symptomatics and during latent stage in asymptomatic animals. However, some of the symptomatic animals showed a low level of filaria-specific IgG as compared to asymptomatic and other symptomatic animals. The immunoblot analysis showed non-reactivity of 17 and 55 kDa antigens with sera of symptomatic animals. The results thus suggest that humoral immune responses as measured in the present study do not precede the development of the manifestations. However, 2 non-reactive antigen molecules identified by symptomatic sera need further study to establish their possible involvement, if any, in the development of acute disease manifestations in this model.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 046574615

Download citation: RISBibTeXText

Related references

Longitudinal cellular immune responses in asymptomatic and symptomatic Brugia malayi-infected Indian leaf monkey Presbytis entellus. Journal of Parasitology 85(5): 861-866, 1999

Longitudinal humoral immune responses of Indian leaf monkey to Brugia malayi infection. Parasitology 119(1): 53-60, 1999

Responses of Brugia malayi - Indian leaf monkey (Presbytis entellus), a non-human primate model of filariasis, to diethylcarbamazine, ivermectin and CDRI compound 82-437. Current Science (Bangalore). 10 February; 863: 432-439, 2004

Brugia malayi in Indian leaf monkey (Presbytis entellus) - response to repeated exposures of infective larvae. Current Science 70(2): 164-167, 1996

Indian langur presbytis entellus as experimental host for brugia malayi infection. Current Science 59(23): 1236-1239, 1990

Preadult stage parasites and multiple timed exposure to infective larvae are involved in development of limb edema in Brugia malayi-infected Indian leaf monkeys (Presbytis entellus). Clinical and Diagnostic Laboratory Immunology 9(4): 913-918, 2002

Experimental infection of the leaf-monkey, Presbytis cristata, with subperiodic Brugia malayi. Parasitology Research 76(8): 689-691, 1990

Experimental infection of the leaf-monkey, Presbytis melalophos with subperiodic Brugia malayi. Tropical Biomedicine 1(1): 21-27, 1984

Hematological changes in subperiodic Brugia malayi infection of the leaf-monkey, Presbytis cristata. Southeast Asian Journal of Tropical Medicine and Public Health 22(2): 168-170, 1991

Effect of ivermectin against subperiodic Brugia malayi infection in the leaf monkey, Presbytis cristata. Parasitology Research 74(4): 383-385, 1988

Filaricidal effect of albendazole against subperiodic Brugia malayi infection in the leaf-monkey, Presbytis melalophos. Tropical Biomedicine 1(2): 121-123, 1984

Chemoprophylactic studies with ivermectin against subperiodic Brugia malayi infection in the leaf monkey, Presbytis cristata. Journal of Helminthology 61(4): 311-314, 1987

Studies on the chemoprophylaxis of subperiodic Brugia malayi infection in the leaf monkey (Presbytis melalophos) with diethylcarbamazine citrate. Zeitschrift für Parasitenkunde 69(5): 677-680, 1983

Leishmania donovani: cellular and humoral immune responses in Indian langur monkeys, Presbytis entellus. Acta Tropica 73(1): 37-48, 1999

Experimental infection of the leaf-monkeys, Presbytis cristata and Presbytis melalophos with subperiodic Brugia malayi. Acta Tropica 47(4): 223-226, 1990