+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Low dose radiation for subfoveal choroidal neovascularization in age-related macular degeneration. A pilot study: radiotherapy for age-related macular degeneration



Low dose radiation for subfoveal choroidal neovascularization in age-related macular degeneration. A pilot study: radiotherapy for age-related macular degeneration



Documenta Ophthalmologica. Advances in Ophthalmology 93(4): 317-326



The aim of our pilot study was to test the effect of low dose radiation on classic and occult subfoveal choroidal neovascularization (CNV) in age-related macular degeneration (AMD). The posterior pole of the afflicted eye of 12 patients was irradiated with 5 Gray (Gy), and that of 34 patients with 8 Gy. The radiotherapy was done by a linear accelerator (6 MV X-rays) during 4 consecutive days with daily doses of 1.25 Gy and 2 Gy respectively. At the time of treatment, and 6 weeks, 6 months and 1 year after, a simultaneous fluorescein and ICG angiography of both eyes were carried out, and the distance visual acuity was measured. In none of the cases were we able to note a reduction in the subfoveal membrane's size. With regards to the visual acuity, the evolution was slightly better than the spontaneous courses described in existing literature. Further prospective randomized studies with higher dose radiation are necessary in order to determine the significance of radiotherapy in the treatment of this pathology.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 046578525

Download citation: RISBibTeXText

PMID: 9665289


Related references

Low dose radiation for subfoveal choroidal neovascularization in age-related macular degeneration: A pilot study. Documenta Ophthalmologica 93(4): 317-326, 1997

Radiotherapy for choroidal neovascularization in age-related macular degeneration. A pilot study using low- versus high-dose photon bean radiation. Der Ophthalmologe 95(10): 691-698, 1998

Long term effects of low-dose radiation therapy on subfoveal choroidal neovascularization in age-related macular degeneration. Investigative Ophthalmology & Visual Science 38(4 Part 1-2): S93, 1997

Macular scatter ('grid') laser treatment of poorly demarcated subfoveal choroidal neovascularization in age-related macular degeneration. Results of a randomized pilot trial. Archives of Ophthalmology 114(12): 1456-1464, 1996

Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration using verteporfin Safety results from an expanded access study, the verteporfin in age-related macular degeneration trial. IOVS 42(4): S305, 2001

Japanese age-related macular degeneration trial: 1-year results of photodynamic therapy with verteporfin in Japanese patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration. American Journal of Ophthalmology 136(6): 1049-1061, 2003

A 5-year follow-up study for distance visual acuity after low dose radiation on subfoveal choroidal neovascularization in age-related macular degeneration. Documenta Ophthalmologica 103(3): 201-209, 2001

A 5-year follow-up study for distance visual acuity after low dose radiation on subfoveal choroidal neovascularization in age-related macular degeneration. Documenta Ophthalmologica. Advances in Ophthalmology 103(3): 201-209, 2001

Progressive growth of subfoveal choroidal neovascularization after radiotherapy in age-related macular degeneration. International Journal of Radiation Oncology Biology Physics 45(3 Suppl. ): 394, 1999

Stereotactic Radiotherapy for Treatment of Subfoveal Choroidal Neovascularization in Age-Related Macular Degeneration. Journal of Radiosurgery 2(2): 113-118, 1999

Radiotherapy For Subfoveal Choroidal Neovascularization In Age-Related Macular Degeneration: A Randomized Clinical Trial. Evidence-Based Eye Care 3(4): 206-207, 2002

Radiotherapy for subfoveal choroidal neovascularization in age-related macular degeneration: A randomized clinical trial. American Journal of Ophthalmology 133(4): 521-529, 2002

Persistent and recurrent neovascularization after successful macular translocation for subfoveal choroidal neovascularization of age-related macular degeneration. IOVS 41(4): S541, 2000

Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials--TAP report. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group. Archives of Ophthalmology 117(10): 1329-1345, 1999

Limited macular translocation for subfoveal choroidal neovascularization in age-related macular degeneration. Clinical and Experimental Ophthalmology 31(2): 103-109, 2003