+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Lymphoma of the marginal zone of the spleen. A case study

Lymphoma of the marginal zone of the spleen. A case study

Medicina Clinica 106(4): 141-143

Lymphomas of the marginal spleen zone are an entity recently considered as separate by the International Lymphoma Study Group. There are B-cell non Hodgkin's lymphomas (NHL) of low grade malignancy with a characteristic phenotype that allows to differentiate from mantle lymphomas and other B-cell lymphoproliferative syndromes. The case of a 69-year-old female patient admitted for abdominal pain due to large splenomegaly is reported. Pancytopenia and the presence of atypical large-sized lymphocytes with extensive cytoplasm and a rounded nucleus with indentations, reticulated appearing chromatin and one or several nucleoli were of note in the hemogram. Microscopic examination of the bone marrow demonstrated moderate-degree lymphocytary infiltration with grade I reticulin fibrosis. Laparotomy with splenectomy was performed. White pulp invasion with multifocal infiltration of the red pulp by lymphocytes of the same characteristics as those observed in the peripheral blood and bone marrow were observed on microscopic bone marrow examination. Immunophenotypic study of these lymphocytes was positive for CD19, CD20 and CD22 while being negative for CD5, CD10, CD23, CD25, CD11c and FMC7, the phenotype belonging to the lymphocytes of marginal spleen zone. Following splenectomy the patient recovered hemoperipheral counts and did not undergo additional treatment. The patient died due to septic shock of respiratory origin 4 months later. The clinical, morphologic and immunophenotypic features of marginal spleen zone lymphomas are reported with emphasis on the differences with other B-cell non Hodgkin's lymphomas of low malignancy.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 046587333

Download citation: RISBibTeXText

PMID: 8948931

Related references

Immunoglobulin and bcl-1 gene rearrangements in splenic marginal zone lymphoma Comparison to a case of mantle cell lymphoma involving the spleen. Modern Pathology 9(1): 112A, 1996

Marginal zone B-cell lymphomas including mucosa-associated lymphoid tissue type lymphoma (MALT), monocytoid B-cell lymphoma and splenic marginal zone cell lymphoma and their relation to the reactive marginal zone. Leukemia and Lymphoma 26(5-6): 467-478, 1997

Comparative study of bone marrow involvement in splenic marginal zone lymphoma and extranodal marginal zone lymphoma. Laboratory Investigation 80(3): 153A, 2000

Marginal zone lymphoma of both spleen and kidney displaying transformation into large B-cell lymphoma. International Urology and Nephrology 38(3-4): 431-437, 2006

Classical Hodgkin lymphoma concurrently evolving in a patient with marginal zone B-cell lymphoma of the spleen. Annals of Diagnostic Pathology 12(3): 212-216, 2008

Composite splenic marginal zone lymphoma and follicular lymphoma A case study utilising interphase fluorescence in-situ hybridisation. Journal of Pathology 201(Suppl.): 24A, 2003

Primary cutaneous marginal zone lymphoma with sequential development of nodal marginal zone lymphoma in a patient with selective immunoglobulin A deficiency. Journal of Cutaneous Pathology 40(12): 1035-1041, 2013

Florid marginal zone differentiation in follicular lymphoma mimicking marginal zone lymphoma of MALT type in the lung. Histopathology 49(4): 426-429, 2006

The marginal zone and marginal sinus in the spleen of the gerbil. A light and electron microscopy study. Journal of Morphology 141(2): 205-215, 1973

A marginal zone phenotype in follicular lymphoma with t(14;18) is associated with secondary cytogenetic aberrations typical of marginal zone lymphoma. Journal of Pathology 209(2): 258-264, 2006

CD5; CD10 marginal zone B cell lymphoma and splenic marginal zone lymphoma Clinical features of 35 cases. Blood 88(10 Suppl. 1 Part 1-2): 189B, 1996

Discordant lymphoma consisting of splenic mantle cell lymphoma and marginal zone lymphoma involving the bone marrow and peripheral blood: a case report. Journal of Medical Case Reports 5: 476, 2011

Genome-wide array-based comparative genomic hybridization of ocular marginal zone B cell lymphoma: comparison with pulmonary and nodal marginal zone B cell lymphoma. Genes Chromosomes and Cancer 46(8): 776-783, 2007

A marginal zone pattern may be found in different varieties of non-Hodgkin's lymphoma: The morphology and immunohistology of splenic involvement by B-cell lymphomas simulating splenic marginal zone lymphoma. Histopathology 33(3): 230-239, 1998