+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Matrix metalloproteinases and angiogenesis

Matrix metalloproteinases and angiogenesis

Current Opinion in Nephrology and Hypertension 11(3): 295-299

Angiogenesis is a prominent feature of numerous diseases, including cancer and arthritis, and appears to play an important role in kidney disease and hypertension. The matrix metalloproteinases, especially matrix metalloproteinase-2, play a vital role during angiogenesis by degrading the surrounding extracellular matrix and allowing endothelial cell invasion. Membrane type 1 matrix metalloproteinase directly degrades matrix components as well as activating matrix metalloproteinase-2 on the cell surface. The integrin receptors, particularly alpha(v)beta(3), can recruit and possibly activate matrix metalloproteinases to localized microdomains on the cell membrane. This restricts matrix metalloproteinase activity to the pericellular region, preventing excessive matrix degradation which would otherwise impede endothelial invasion. Inhibitors of matrix metalloproteinase activity may actually promote cell invasion by preventing uncontrolled matrix degradation. In addition to degrading the matrix, matrix metalloproteinases produce protein fragments that impede their angiogenic action. These multiple regulatory pathways permit fine control over cell invasion during angiogenesis and provide new, precise strategies for targeting abnormal angiogenesis, through control of matrix metalloproteinase activity.

(PDF emailed within 0-6 h: $19.90)

Accession: 046631309

Download citation: RISBibTeXText

PMID: 11981259

DOI: 10.1097/00041552-200205000-00005

Related references

The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma. Korean Journal of Gastroenterology 45(6): 401-408, 2005

Expressions of angiogenesis associated matrix metalloproteinases and extracellular matrix proteins in cerebral vascular malformations. Journal of Clinical Neuroscience 17(2): 232-236, 2010

Tissue inhibitor of metalloproteinases-1-mediated inhibition of in vitro angiogenesis is unrelated to its function as an inhibitor of matrix metalloproteinases. Proceedings of the American Association for Cancer Research Annual Meeting 37(0): 93, 1996

Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases. Cancer Research 65(8): 3193-3199, 2005

Matrix metalloproteinases and angiogenesis. Journal of Cellular and Molecular Medicine 9(2): 267-285, 2005

Matrix metalloproteinases and matrikines in angiogenesis. Critical Reviews in Oncology/Hematology 49(3): 203-220, 2004

Plasminogen activators and matrix metalloproteinases in angiogenesis. Enzyme and Protein 49(1-3): 117-137, 1996

The role of matrix metalloproteinases and their tissue inhibitors in angiogenesis. Polski Merkuriusz Lekarski 21(121): 80-85, 2006

Roles of matrix metalloproteinases in tumor metastasis and angiogenesis. Journal of Biochemistry and Molecular Biology 36(1): 128-137, 2003

Matrix metalloproteinases -2 and -9 in pig luteal tissue angiogenesis and angioregression. Veterinary Research Communications 31(Suppl.1): 193-196, 2007

Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead. Cardiovascular Research 78(2): 203-212, 2007

Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis. Drug Discovery Today 6(9): 478-482, 2001

Effect of simvastatin on serum matrix metalloproteinases-1, matrix metalloproteinases-9, tissue inhibitor of metalloproteinases-1, high sensitive C-reactive protein levels in patients of acute coronary syndrome in serum normocholesterolemia and hypercholesterolemia level. Zhonghua Xinxueguanbing Zazhi 32(2): 109-113, February 19, 2004

Matrix metalloproteinases -2 and -9 in swine luteal tissue angiogenesis and angioregression. Veterinary Research Communications 31 Suppl 1: 193-196, 2007

Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention. Journal of Clinical Investigation 103(9): 1237-1241, 1999