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Matrix metalloproteinases in patients with osteoarthritis of the hip



Matrix metalloproteinases in patients with osteoarthritis of the hip



International Orthopaedics 24(2): 92-96



In 78 patients undergoing a total hip replacement we examined the production of matrix metalloproteinases (MMP) by the fibroblasts from the connective tissue of the acetabulum; we then correlated these findings with clinical and radiological characteristics of the same patients. In 53 patients only MMP-2 was produced; in 15 cases MMP-1, -2 and -3 were present; and in 10 cases not only MMP-1, -2, -3 but also MMP-9. Significant differences among the clinical and radiological parameters were found in the 3 subsets. A positive correlation between the production of MMP-9 and a rapid destruction of the hip joint was found.

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Accession: 046631378

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PMID: 10894378

DOI: 10.1007/s002640000110


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