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Matrix production of smooth muscle cells from rat aorta in vitro

Matrix production of smooth muscle cells from rat aorta in vitro

Histology and Histopathology 8(1): 63-72

Immunofluorescence microscopic methods served to demonstrate the production of the following matrix components in cultures of vascular smooth muscle cells from rat aorta: fibronectin; nidogen; heparan sulphate-proteoglycan (HS-PG); laminin; and collagen types I, III, IV, V, and VI. A time-dependence of synthesis and secretion could be shown for a number of components of the extracellular matrix (ECM), such as laminin. The results revealed the following estimated quantitative differences of the collagen types: type I > type III > types V and VI. A filamentous/fibrillar matrix and also occasionally a typical basal lamina could be demonstrated electron microscopically around the smooth muscle cells.

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Accession: 046631444

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PMID: 8443436

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