+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Matrix proteins and mineralization: an overview

Matrix proteins and mineralization: an overview

Connective Tissue Research 35(1-4): 357-363

There is a wealth of information on the mineral and matrix components in bones and teeth, in the exoskeletons of invertebrates, and in dystrophic calcific deposits. This information includes detailed characterization of their physical and chemical composition and details on the gene localization and regulation of gene expression for the major and minor protein constituents. The reason that mineral deposition occurs in some tissues and not in others remains unclear. In this review, studies in solution, cell culture studies, and investigations in mutant animals will be surveyed to indicate which matrix proteins may affect mineralization. Most of the molecules that appear to be involved in initiation and regulation of biological mineral formation are anionic; they have structural features that facilitate interaction with mineral, cells, and other matrix molecules, and they can have more than one function. Despite extensive data it is not yet clear which of these molecules is absolutely essential for physiologic calcification in each of the calcified tissues.

(PDF emailed within 0-6 h: $19.90)

Accession: 046631447

Download citation: RISBibTeXText

PMID: 9084675

DOI: 10.3109/03008209609029212

Related references

Extracellular matrix mineralization in periodontal tissues: Noncollagenous matrix proteins, enzymes, and relationship to hypophosphatasia and X-linked hypophosphatemia. Periodontology 2000 63(1): 102-122, 2015

Symposium on matrix proteins as templates for mineralization. Anatomical Record 224(2): 123-324, 1989

Bone matrix proteins and the mineralization process. Favus, M J Primer on the metabolic bone diseases and disorders of mineral metabolism, Third edition: 24-28, 1996

Noncollagenous matrix proteins and their role in mineralization. Bone and Mineral 6(2): 111-123, 1989

Bone matrix proteins and mineralization process. Favus, M J Primer on the metabolic bone diseases and disorders of mineral metabolism, Second edition: 21-25, 1993

Extracellular processing of bone and dentin proteins in matrix mineralization. Connective Tissue Research 35(1-4): 223-229, 1996

Mineralization and the expression of matrix proteins during in vivo bone development. Calcified Tissue International. 62(1): 74-82,., 1998

Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. Journal of Cell Biology 165(5): 625-630, 2004

Pattern of mineralization after regenerative periodontal therapy with enamel matrix proteins. European Journal of Oral Sciences 114 Suppl 1: 225-31; Discussion 254-6, 381-2, 2006

The studies on osteoblasts' mineralization and attachment affected by enamel matrix proteins. Shanghai Kou Qiang Yi Xue 11(2): 135-137, 2004

Avian eggshell mineralization: biochemical and functional characterization of matrix proteins. Comptes Rendus Palevol ober; 3(6-7): 549-562, 2004

The matrix proteins of dental enamel an overview. Calcified Tissue International 39(SUPPL): A9-A11, 1986

Electrophoretic gels of dentin matrix proteins as diffusion media for in vitro mineralization. Journal of Dental Research 75(6): 1381-1387, 1996

Amelogenins: major extracellular matrix proteins regulating tooth enamel mineralization. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme 38(5): 811-820, 1993

Messenger RNA for estrogen receptor and matrix mineralization proteins in human coronary arteries. Clinical Research 42(2): 177A, 1994