+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Maturation of human hypothalamic-pituitary-thyroid function and control



Maturation of human hypothalamic-pituitary-thyroid function and control



Thyroid 10(3): 229-234



Measurements of serum thyrotropin (TSH) and free thyroxine (T4) concentrations were conducted in infants, children, and adults to assess maturation of the hypothalamic-pituitary-thyroid (HPT) feedback control axis. Serum free T4 and TSH concentration data were collated for cord blood of the midgestation fetus, for premature and term infants, and for peripheral blood from newborn infants, children, and adults. Mean values were plotted on a nomogram developed to characterize the reference ranges of the normal axis quantitatively based on data from 522 healthy subjects, 2 weeks to 54 years of age; 83 untreated hypothyroid patients; and 116 untreated hyperthyroid patients. Samples for 75 patients with thyroid hormone resistance were also plotted. The characterized pattern of HPT maturation included a progressive decrease in the TSH/free T4 ratio with age, from 15 in the midterm fetus, to 4.7 in term infants, and 0.97 in adults. Maturation plotted on the nomogram was complex, suggesting increasing hypothalamic-pituitary T4 resistance during fetal development, probably secondary to increasing thyrotropin-releasing hormone (TRH) secretion, the marked, cold-stimulated TRH-TSH surge at birth with reequilibration by 2-20 weeks, and a final maturation phase characterized by a decreasing serum TSH with minimal change in free T4 concentration during childhood and adolescence. The postnatal maturative phase during childhood and adolescence correlates with the progressive decrease in thyroxine secretion rate (on a microg/kg per day basis) and metabolic rate and probably reflects decreasing TRH secretion.

(PDF emailed within 0-6 h: $19.90)

Accession: 046631731

Download citation: RISBibTeXText

PMID: 10779137

DOI: 10.1089/thy.2000.10.229


Related references

Maturation of hypothalamic pituitary control of thyroid function in the human fetus. Pediatric Research 4(5): 457, 1970

The ontogenesis of pituitary hormones and hypothalamic factors in the human fetus: maturation of central nervous system regulation of anterior pituitary function. Recent Progress in Hormone Research 32: 161-243, 1976

The effect of human growth hormone on hypothalamic pituitary thyroid function in patients with pituitary dwarfism. Acta Endocrinologica 93(1): 13-19, 1980

Hypothalamic and pituitary control of thyroid function. Pan American Health Organization Scientific Publication 292: 33-42, 1974

Depression and alterations in hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid axis function in male abstinent methamphetamine abusers. Human Psychopharmacology 28(5): 477-483, 2014

Neurotransmitter control of hypothalamic-pituitary-thyroid function in rats. European Journal of Pharmacology 70(3): 263-271, 1981

Hypopituitarism in the elderly: a narrative review on clinical management of hypothalamic-pituitary-gonadal, hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes dysfunction. Journal of Endocrinological Investigation 39(10): 1115-1124, 2017

Ontogenesis of hypothalamic pituitary thyroid function in the human fetus. Delange, F , D A Fisher And P Malvaux (Ed ) Pediatric And Adolescent Endocrinology, Vol 14 Pediatric Thyroidology Xii+412p S Karger: Basel, Switzerland; New York, N Y , Usa Illus 19-32, 1985

Studies on dys function of hypothalamic pituitary thyroid axis part 1 studies on dys function of hypothalamic pituitary thyroid axis in chronic thyroiditis. Medical Journal of Kobe University 36(3): 1-8, 1977

Studies on dys function of hypothalamic pituitary thyroid axis part 2 studies on dys function of hypothalamic pituitary thyroid axis in breast cancer. Medical Journal of Kobe University 36(3): 9-16, 1977

Maturation of hypothalamic-pituitary-thyroid response in the rat to acute cold. American Journal of Physiology 239(3): E223-E226, 1980

The effect of vitamin D and selenomethionine on thyroid antibody titers, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in men with Hashimoto's thyroiditis: A pilot study. Pharmacological Reports 71(2): 243-247, 2019

Impairment of hypothalamic-pituitary-thyroid function in rats treated with human recombinant tumor necrosis factor-alpha (cachectin). Endocrinology 125(1): 76-84, 1989

Function of thyroid and hypothalamic pituitary thyroid axis in radio iodine treated thyro toxic patients. Endokrinologie 76(3): 345-350, 1980

Evolution of hypothalamic pituitary thyroid function in a suspected homozygotic child with generalized resistance to thyroid hormone. Pediatric Research 27(4 PART 2): 83A, 1990