+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Maturation of mass-screened localized adrenal neuroblastoma



Maturation of mass-screened localized adrenal neuroblastoma



Journal of Pediatric Surgery 36(11): 1633-1636



In infants, neuroblastoma has been known to spontaneously differentiate into a benign ganglioneuroma. Although several investigators have compared mass-screened with unscreened, disseminated with localized, and adrenal with retroperitoneal neuroblastoma, there are very few cross-comparisons of the above parameters. Herein, the authors report the maturation of mass-screened, localized adrenal neuroblastoma. Fifty-one mass-screened adrenal neuroblastomas were divided into 2 groups. In infants less than 1 year of age (Group A), 45 neuroblastomas were resected, whereas 6 neuroblastomas were resected after observation in 1- to 4-year-old children (group B). Histopathology of the tumors in the 2 groups was compared. Data were analyzed by X(2) test, and P <.05 was considered significant. According to the International Neuroblastoma Pathological Classification, 41 of 45 tumors of group A were "differentiating neuroblastoma" and 4 of 6 tumors of group B were "maturing ganglioneuroma." Maturation toward ganglioneuroblastoma was observed in 16 neuroblastomas of group A (36%) and 6 neuroblastomas of group B (100%). In group A, 58% had low mitosis karyorrhexis index (MKI); all patients in group B had low MKI. If left untreated, maturation of mass-screened, localized adrenal neuroblastomas is a common phenomenon. These children do not need to undergo early operation.

(PDF emailed within 0-6 h: $19.90)

Accession: 046631746

Download citation: RISBibTeXText

PMID: 11685689

DOI: 10.1053/jpsu.2001.27935


Related references

Laparoscopic resection of mass-screened adrenal neuroblastoma in an 8-month-old infant. Surgical Laparoscopy and Endoscopy 7(6): 498-500, 1998

Biological analysis of neuroblastoma in mass screened negative cases. Progress in Clinical and Biological Research 366: 603-608, 1991

Extirpation of mass-screened adrenal neuroblastomas by retroperitoneoscopy. Surgical Endoscopy 17(11): 1769-1772, 2003

Maturation Of Congenital Extra-Adrenal Neuroblastoma. Archives of Pathology 76: 121-125, 1963

Clinicopathologic study of mass-screened neuroblastoma with special emphasis on untreated observed cases: a possible histologic clue to tumor regression. American Journal of Surgical Pathology 24(6): 807-815, 2000

Long-term follow-up of the "wait and see" approach to localized perinatal adrenal neuroblastoma. World Journal of Surgery 37(2): 459-465, 2013

Prognostic value of International Neuroblastoma Pathology Classification in localized resectable peripheral neuroblastic tumors: a histopathologic study of localized neuroblastoma European Study Group 94.01 Trial and Protocol. Journal of Clinical Oncology 24(4): 695-699, 2006

Spontaneous regression of localized neuroblastoma detected by mass screening. Journal of Clinical Oncology 16(4): 1265-1269, 1998

Adult neuroblastoma: a rare diagnosis of an adrenal mass. Bmj Case Reports 12(4), 2019

"Wait and see" strategy in localized neuroblastoma in infants: an option not only for cases detected by mass screening. Pediatric Blood and Cancer 43(6): 679-682, 2004

Adrenal neuroblastoma with metastatic mandibular mass: An unusual presentation. Journal of Cancer Research and Therapeutics 11(3): 645, 2016

Extra-Adrenal Adult Neuroblastoma With Aberrant Germ Cell Marker Expression: Maturation After Chemotherapy as an Important Clue to a Challenging Diagnosis. International Journal of Surgical Pathology 2019: 1066896919835945, 2019

Mass spectrometry of gangliosides in extracranial tumors: Application to adrenal neuroblastoma. Analytical Biochemistry 509: 1-11, 2017

An infant with bilateral adrenal neuroblastoma found by mass-screening: report of a case. Surgery Today 23(6): 546-550, 1993

A "screened" electrostatic ion trap for enhanced mass resolution, mass accuracy, reproducibility, and upper mass limit in Fourier transform ion cyclotron resonance mass spectrometry. Analytical Chemistry 61(11): 1288-1293, 1989