+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells



Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells



Radiation Research 155(1 Pt 2): 230-234



Carcinogenesis is a multistage process with sequences of genetic events that govern the phenotypic expression of a series of transformation steps that lead to the development of metastatic cancer. To better understand the mechanisms involved in human bronchial carcinogenesis induced by alpha particles from radon, we have developed a model of neoplastic transformation based on human papillomavirus-immortalized human bronchial epithelial (BEP2D) cells. Cells exposed to alpha particles become tumorigenic after progressing through a series of sequential stages including altered growth pattern, resistance to serum-induced terminal differentiation, agar-positive growth, tumorigenicity, and metastasis, with each step representing a necessary yet insufficient step toward the later, more malignant phase. Cell fusion studies indicated that the radiation-induced tumorigenic phenotype in BEP2D cells can be completely suppressed by fusion with nontumorigenic BEP2D cells. Several cellular differentiation and growth regulation genes such as DCC (deleted in colorectal cancer), CDKN1A (also known as p21(C1P1)) and the gene that encodes DNA-PK were frequently found to be modulated in tumorigenic BEP2D cells and may be related to the process of carcinogenesis.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 046645656

Download citation: RISBibTeXText

PMID: 11121239


Related references

Mechanisms of Radiation-Induced Neoplastic Transformation of Human Bronchial Epithelial Cells. Radiation Research 155(1): 230-234, 2001

Part 2 || Mechanisms of Radiation-Induced Neoplastic Transformation of Human Bronchial Epithelial Cells. Radiation Research 155(1): 230-234, 2001

Radon-induced neoplastic transformation of human bronchial epithelial cells. Radiation Oncology Investigations 3(6): 398-403, 1995

Radiation-induced neoplastic transformation of human prostate epithelial cells. Cancer Research 56(1): 5-10, 1996

Cytoskeletal changes during radiation-induced neoplastic transformation of human prostate epithelial cells. Scanning Microscopy 10(4): 1093, 1996

Cigarette smoke-induced failure of apoptosis resulting in enhanced neoplastic transformation in human bronchial epithelial cells. Journal of Toxicology and Environmental Health. Part a 75(12): 707-720, 2012

Effect of retinol on radiation- and estrogen-induced neoplastic transformation of human breast epithelial cells. Oncology Reports 13(6): 1017-1027, 2005

SKY and CGH analysis of genetic changes involved in radiation-induced neoplastic transformation of human prostate epithelial cells. American Journal of Human Genetics 61(4 Suppl. ): A80, 1997

Genetic and epigenetic mechanisms in the radiation-induced neoplastic transformation of human hybrid cells. Photochemistry & Photobiology 69(SPEC ISSUE ): 93S, 1999

Allelic imbalance at 11p15.5-15.4 correlated with c-Ha-ras mutation during radiation-induced neoplastic transformation of human breast epithelial cells. International Journal of Cancer 103(6): 730-737, 2003

Frequent allelic imbalance on chromosome 6 and 17 correlate with radiation-induced neoplastic transformation of human breast epithelial cells. Carcinogenesis 22(10): 1685-1692, 2001

Molecular mechanisms of radiation-induced transformation of human mammary epithelial cells. International Journal of Radiation Oncology Biology Physics 30(Suppl. 1): 184, 1994

Growth differentiation and neoplastic transformation of human bronchial epithelial cells. Harris, C C (Ed ) Ucla (University Of California Los Angeles) Symposia on Molecular And Cellular Biology New Series, Vol 40 Biochemical And Molecular Epidemiology Of Cancer; Abbott Laboratories-Ucla Symposium, Steamboat Springs, Colo , Usa, Apr 6-13, 1985 Xix+473p Alan R Liss, Inc : New York, N Y , Usa Illus 213-226, 1986

Neoplastic transformation of human bronchial epithelial cells by activated proto oncogenes. Clinical Research 37(2): 577A, 1989

Neoplastic transformation of human bronchial epithelial cells following transfection with sv 40 virus early region genes. Proceedings of the American Association for Cancer Research Annual Meeting 30: 218, 1989