+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Membrane filtration of pharmaceutical solutions



Membrane filtration of pharmaceutical solutions



American Journal of Hospital Pharmacy 50(9): 1921-1936



The principles and uses of membrane filtration in the preparation of pharmaceutical solutions are discussed. The preparation of pharmaceutical solutions often requires their passage through a thin polymeric membrane containing many tiny pores. The purpose is to remove viable and nonviable particles in order to clarify or sterilize the solution. Particles may be retained by sieving, entrapment, or electrostatic attraction. The largest pore size that will yield a sterile filtrate is 0.2 microns. Membrane filters are either hydrophobic or hydrophilic. The rate of flow through a filter is affected by the resistance of the filter, the viscosity of the solution, and pressure. Filters are commonly composed of mixed esters of cellulose, polysulfone, polyvinylidene difluoride, nylon 66, polycarbonate, or polytetrafluoroethylene. In selecting a membrane filter, a pharmacist must consider pore size, compatibility, fluid volume, particulate load, and the filter holder. Various tests are available to evaluate the integrity of filters. Filters are useful in testing end products for sterility. The use of an in-line filter during the administration of large-volume injectable solutions can prevent the introduction of particles, air, and microorganisms into the patient. Therapies in which a 0.2-micron filter may be contraindicated include lipid emulsions, low-dose infusions, low-volume infusions, drugs for which the pharmacologic properties are altered by the membrane filter, and drugs that adhere to the membrane. Pharmacists need an in-depth understanding of the principles of filtration, the characteristics of filters, and their use in the filtration of pharmaceutical solutions.

(PDF emailed within 0-6 h: $19.90)

Accession: 046661385

Download citation: RISBibTeXText

PMID: 8135243

DOI: 10.1093/ajhp/50.9.1921


Related references

On the Filtration of Injectable Solutions in Pharmaceutical Practice. Aptechnoe Delo 12: 59-62, 1963

Effective filtration solutions for the biotechnology, biologics, and pharmaceutical industries. American Biotechnology Laboratory 17(3): 52-53, 1999

Hybrid membrane filtration-advanced oxidation processes for removal of pharmaceutical residue. Journal of Colloid and Interface Science 532: 236-260, 2018

Microbiological control of pharmaceutical products containing preservatives: drawbacks of the method of membrane filtration. Bollettino Chimico Farmaceutico 131(7): 274-283, 1992

The removal of bacteria from solutions by membrane filtration. Journal of Microbiological Methods 16(3): 215-220, 1992

Control of microbial contamination in oral and topical pharmaceutical preparations by membrane filtration method. Il Farmaco; Edizione Pratica 26(4): 224-229, 1971

Application of membrane filtration for removal of diminutive bioburden organisms in pharmaceutical products and processes. Pda Journal of Pharmaceutical Science and Technology 53(4): 186-201, 2001

An assessment of the cleaning solutions’ purification by membrane filtration. Desalination and Water Treatment 51(7-9): 1366-1376, 2013

Preparation of sterile parenteral hyperalimentation solutions by membrane filtration. American Journal of Hospital Pharmacy 28(5): 370-372, 1971

A new apparatus to control sterility of solutions and soluble products during membrane filtration. Nuovi Ann Ig Microbiol 17(3): 213-218, 1966

The filtration of protein solutions across films of renal basement membrane in vitro. Biochemical Society Transactions 6(6): 1356-1358, 1978

Crystallization of calcium carbonate with the filtration of aqueous solutions through a microporous membrane. Russian Journal of Physical Chemistry A, Focus on Chemistry 91(11): 2121-2123, 2017

Sterility testing of large volume aqueous pharmaceutical products intra venous solution by the membrane filtration technique. Canadian Journal of Pharmaceutical Sciences 8(1): 23-25, 1973

A membrane filtration method for estimating the number of viable bacteria in solutions containing antibiotic. Acta Microbiologica Polonica 30(4): 407-411, 1981

Purification and regeneration of diluted caustic and acidic washing solutions by membrane filtration. Desalination 0, 149(1-3): 185-190, 2002