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Membrane lipid microdomains and the role of PKCtheta in T cell activation



Membrane lipid microdomains and the role of PKCtheta in T cell activation



Seminars in Immunology 13(2): 139-146



Productive T cell activation depends on the assembly of a highly ordered and compartmentalized immunological synapse or supramolecular activation complex (SMAC). Reorganization of the actin cytoskeleton and clustering of specialized membrane microdomains, or lipid rafts, occur early following TCR/CD3 and costimulatory receptor ligation. Many key signaling molecules localize in lipid raft patches during T cell activation. Lipid raft reorganization is required for T cell activation, where it plays an apparently important role in stabilizing the T cell synapse. Here we review recent evidence supporting the role of lipid rafts in T cell activation. Particular emphasis is placed on the coupling of protein kinase C-theta(PKCtheta), which is selectively expressed in T cells and is known to function as an essential signal for T cell activation, and lipid rafts.

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Accession: 046661491

Download citation: RISBibTeXText

PMID: 11308297

DOI: 10.1006/smim.2000.0305


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