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Membrane organization in immunoglobulin E receptor signaling



Membrane organization in immunoglobulin E receptor signaling



Current Opinion in Chemical Biology 3(1): 95-99



The structure and dynamics of the plasma membrane are proposed to be critical for the initial steps of signal transduction by the high-affinity immunoglobulin E receptor. Recent experimental advances indicate that interactions between the high-affinity immunoglobulin E receptor and the tyrosine kinase Lyn with cholesterol- and sphingolipid-rich regions within the plasma membrane are important for receptor function. This accumulating evidence points to spatio-temporal control of immunoglobulin E receptor signaling by the organization of the plasma membrane; an attractive hypothesis is that ligand-dependent receptor aggregation causes the segregation of Lyn-containing ordered regions of the plasma membrane from disordered regions.

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Accession: 046661524

Download citation: RISBibTeXText

PMID: 10021405

DOI: 10.1016/s1367-5931(99)80017-9


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