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Membrane raft microdomains in chemokine receptor function



Membrane raft microdomains in chemokine receptor function



Seminars in Immunology 13(2): 147-157



Cell chemotaxis requires the acquisition and maintenance of both spatial and functional asymmetry between initially equivalent cell parts. In leukocytes one becomes the leading edge and the other, the rear edge or uropod. The acquisition of this cell polarity is controlled by an array of chemoattractants, including those of the chemokine family. We propose that chemokine receptor activation in highly organized lipid raft domains is a major determinant for the correct localization of the signaling pathways leading to the cell asymmetries required for migration. The lateral organization imposed by membrane raft microdomains is discussed in the context of other chemokine receptor activities, such as its role as a human immunodeficiency virus (HIV) coreceptor.

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Accession: 046661664

Download citation: RISBibTeXText

PMID: 11308298

DOI: 10.1006/smim.2000.0306


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