+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Analysis of Association of Angiotensin II Type 1 Receptor Gene A1166C Gene Polymorphism with Essential Hypertension



Analysis of Association of Angiotensin II Type 1 Receptor Gene A1166C Gene Polymorphism with Essential Hypertension



Indian Journal of Clinical Biochemistry 33(1): 53-60



The A/C transversion at 1166 of the angiotensin II Type 1 Receptor (AT1R) gene per se does not characterize any functional diversity but has been associated with expression of the AT1R, consequently molecular variants of the gene may modulate the possible risk of essential hypertension. The present study was performed to determine the genotypic frequency of the A1166C polymorphism of the AT1R gene in essential hypertensive patients with the aim to assess the effect of variants of this polymorphism in hypertension. AT1R gene amplification was performed by PCR and A1166C polymorphism was determined by enzyme digestion methodologies in 224 consecutively enrolled essential hypertensive patients and 257 controls. Suitable descriptive statistics was used for different variables. Results revealed that genotype and allele distribution of the A1166C variant differed significantly in hypertensives and normotensives. Allele frequency at the A1166C position was 61%A and 39%C for control and 52%A and 48%C for patients. Observed frequencies were compatible with HWE expected frequencies in cases as well as in controls. rs5186 was found to be associated with hypertension (95% CI 1.1453-2.7932, p: 0.0106). The difference remained statistically significant after the multivariate adjustment (p < 0.05), with C/C variant conferring a risk of 1.74-fold of essential hypertension. This association was confirmed by inter-genotypic variations in the mean systolic and diastolic blood pressure in patients. In conclusion, genetic variation at the AT1R gene influences the risk of hypertension stratification and might serve as a predictive marker for the susceptibility to hypertension among affected families.

(PDF emailed within 0-6 h: $19.90)

Accession: 046676122

Download citation: RISBibTeXText

PMID: 29371770

DOI: 10.1007/s12291-017-0644-7


Related references

Angiotensin II type 1 receptor gene A1166C polymorphism and essential hypertension in Chinese: a meta-analysis. Journal of the Renin-Angiotensin-Aldosterone System 11(2): 127-135, 2010

Association of angiotensin II type 1 receptor (A1166C) gene polymorphism and its increased expression in essential hypertension: a case-control study. Plos One 9(7): E101502, 2015

Angiotensin II type 1 receptor A1166C gene polymorphism and essential hypertension in San Luis. Biocell 30(3): 447-455, 2007

A1166C Polymorphism of the Angiotensin Ii Type 1 Receptor Gene and Essential Hypertension in Han, Tibetan and Yi Populations. Hypertension Research 25(4): 515-521, 2002

A1166C polymorphism of the angiotensin II type 1 receptor gene and essential hypertension in Han, Tibetan and Yi populations. Hypertension Research 25(4): 515-521, 2002

Angiotensin II type 1 receptor A1166C gene polymorphism and essential hypertension in Calabar and Uyo cities, Nigeria. Indian Journal of Human Genetics 19(2): 213-218, 2013

Analysis of the postulated interaction between the angiotensin II sub-type 1 receptor gene A1166C polymorphism and the insertion/deletion polymorphism of the angiotensin converting enzyme gene on risk of myocardial infarction. Atherosclerosis 154(1): 123-128, 2001

A1166C polymorphism of the angiotensin II type 1 receptor gene contributes to hypertension susceptibility: evidence from a meta-analysis. Acta Cardiologica 72(2): 205-215, 2017

Association of angiotensin ІІ type 1 receptor gene A1166C polymorphism with cancer risk: An updated meta-analysis. Journal of the Renin-Angiotensin-Aldosterone System 20(1): 1470320319827207, 2019

Angiotensin II type 1 receptor A1166C gene polymorphism. Absence of an association with the risk of coronary artery disease and myocardial infarction and of a synergistic effect with angiotensin-converting enzyme gene polymorphism on the risk of these diseases. European Heart Journal 19(11): 1657-1665, 1998

A systematic review and meta-analysis of the association between angiotensin II type 1 receptor A1166C gene polymorphism and myocardial infarction susceptibility. Journal of the Renin-Angiotensin-Aldosterone System 15(3): 307-315, 2015

Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations. Journal of the Renin-Angiotensin-Aldosterone System 14(1): 82-90, 2013

Association between the A1166C polymorphism of the angiotensin II receptor type 1 gene and schizophrenia. American Journal of Medical Genetics 114(7): 841, October 8, 2002

Association between the A1166C polymorphism of the angiotensin II receptor type 1 gene and social phobia in men. American Journal of Medical Genetics 114(7): 839, October 8, 2002

Association of angiotensin II type 1 receptor gene polymorphism with essential hypertension. Chinese Medical Journal (English Edition) 114(12): 1249-1251, 2001