+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Methods of meta-analysis: an analysis

Methods of meta-analysis: an analysis

Current Opinion in Clinical Nutrition and Metabolic Care 5(5): 467-474

To understand the principles of systematic reviewing and meta-analysis, using recent examples from the medical literature to highlight some of these points. The word 'meta-analysis' is an intimidating one, and its associated jargon makes it seem incomprehensible. Actually, it is only a mathematical maneuver to add up data in a systematic review; it might be better called 'meta-addition'. The systematic review is a process of using the best available evidence to answer a particular clinical question. Data combination (usually done with meta-analysis) increases the power to see small differences and makes a more precise estimate of a treatment effect. Its major drawback is heterogeneity (the proverbial problem of adding apples and oranges). Systematic reviews have been used by medical societies to create position statements. Such statements have suggested that parenteral nutrition is far less efficacious than previously believed. Systematic reviews in some areas of nutritional support have clarified type II errors. Problems exist, however, in a number of the published meta-analyses of aspects of this therapy. Especially in an era of resource restraint, we need to become more skilled at interpreting evidence from clinical research.

(PDF emailed within 0-6 h: $19.90)

Accession: 046676297

Download citation: RISBibTeXText

PMID: 12172468

DOI: 10.1097/00075197-200209000-00003

Related references

Extending methods for investigating the relationship between treatment effect and baseline risk from pairwise meta-analysis to network meta-analysis. Statistics in Medicine 32(5): 752-771, 2013

Oral direct factor Xa inhibitor versus enoxaparin for thromboprophylaxis after hip or knee arthroplasty: Systemic review, traditional meta-analysis, dose-response meta-analysis and network meta-analysis. Thrombosis Research 136(6): 1133-1144, 2016

Systematic Review and Meta-Analysis of Studies Evaluating Diagnostic Test Accuracy: A Practical Review for Clinical Researchers-Part II. Statistical Methods of Meta-Analysis. Korean Journal of Radiology 16(6): 1188-1196, 2016

Are meta-analysis methods valid Reverse meta-analysis. Journal of the American College of Cardiology 27(2 SUPPL A): 89A, 1996

Does Race Influence Risk Assessment and Recommendations for Lung Resection? A Randomized Trial. Annals of Thoracic Surgery, 2018

Methods for association analysis and meta-analysis of rare variants in families. Genetic Epidemiology 39(4): 227-238, 2015

Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: Methods and power analysis. American Journal of Human Genetics 73(1): 17-33, 2003

Methods to induce labour: a systematic review, network meta-analysis and cost-effectiveness analysis. Bjog 123(9): 1462-1470, 2016

Statistical analysis methods for meta-analysis of times to emergence. European Journal of Anaesthesiology 32(7): 506-506, 2016

Mega-analysis of meta-analysis: An examination of meta-analysis with an emphasis on once-daily aminoglycoside comparative trials. Pharmacotherapy 16(6): 1093-1102, 1996

Applied behavior analytic intervention for autism in early childhood: meta-analysis, meta-regression and dose-response meta-analysis of multiple outcomes. Clinical Psychology Review 30(4): 387-399, 2010

The impact of data-analysis methods on cumulative research knowledge: statistical significance testing, confidence intervals, and meta-analysis. Evaluation & the Health Professions 18(4): 408-427, 1995

A collaborative sequential meta-analysis of individual patient data from randomized trials of endovascular therapy and tPA vs. tPA alone for acute ischemic stroke: ThRombEctomy And tPA (TREAT) analysis: statistical analysis plan for a sequential meta-analysis performed within the VISTA-Endovascular collaboration. International Journal of Stroke 10 Suppl A100(): 136-144, 2016