+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Methotrexate loaded chitosan and chitin microspheres--in vitro characterization and pharmacokinetics in mice bearing Ehrlich ascites carcinoma



Methotrexate loaded chitosan and chitin microspheres--in vitro characterization and pharmacokinetics in mice bearing Ehrlich ascites carcinoma



Journal of Microencapsulation 15(5): 581-594



Methotrexate (MTX) loaded chitosan and chitin microspheres were prepared. The physicochemical characteristics were affected by various parameters, e.g. stirring speed, concentration of chitosan and chitin. The t1/2 for in vitro release varied depending on the concentration of chitosan and chitin and the amount of glutaraldehyde used. The antitumour activity in Ehrlich ascites tumour bearing mice for MTX loaded chitosan microspheres was better when compared with plane MTX on oral administration. The plasma drug levels were sustained.

(PDF emailed within 0-6 h: $19.90)

Accession: 046676711

Download citation: RISBibTeXText

PMID: 9743914

DOI: 10.3109/02652049809008242


Related references

Antitumour activity of mitoxantrone-loaded chitosan microspheres against Ehrlich ascites carcinoma. Journal Of Pharmacy & Pharmacology. 48(7): 685-688, 1996

In vitro characterization of methotrexate loaded poly(lactic-co-glycolic) acid microspheres and antitumor efficacy in Sarcoma-180 mice bearing tumor. Pharmaceutica Acta Helvetiae 72(3): 165-173, 1997

Acylated chitosan anchored paclitaxel loaded liposomes: Pharmacokinetic and biodistribution study in Ehrlich ascites tumor bearing mice. International Journal of Biological Macromolecules 122: 367-379, 2018

Anti-Tumor Effect of Mitoxantrone-Loaded Bovine Casein Microspheres on Ehrlich Ascites Carcinoma in Mice. Drug Delivery 3(2): 75-79, 1996

Trehalose enhances the antitumor potential of methotrexate against mice bearing Ehrlich ascites carcinoma. Biomedicine and PharmacoTherapy 92: 870-878, 2017

Preparation, characterization, and biodistribution of letrozole loaded PLGA nanoparticles in Ehrlich Ascites tumor bearing mice. International Journal of Pharmaceutics 397(1-2): 194-200, 2011

Preparation, characterization, and biodistribution study of technetium-99m -labeled leuprolide acetate-loaded liposomes in Ehrlich ascites tumor-bearing mice. Aaps Pharmsci 6(1): E5, 2004

Organ weights of TE mice bearing Ehrlich ascites carcinoma growing in the solid form and of C3H mice bearing spontaneous mammary carcinoma. Experientia 14(8): 299-300, 1958

The effect of immune rabbit thoracic lymphocytes against ehrlich carcinoma upon the prolongation of survival of ehrlich ascites tumor bearing mice. Journal of Catholic Medical College 21: 333-345, 1971

Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma. Drug Delivery 17(3): 103-113, 2010

Efficacy of methotrexate-loaded poly(ε-caprolactone) implants in Ehrlich solid tumor-bearing mice. Drug Delivery 20(3-4): 168-179, 2014

The reversal of effects of methotrexate on toxicity and glucose transport reduction by thymidine in Ehrlich ascites tumor bearing mice. Cancer Biochemistry Biophysics 8(4): 249-256, 1986

Fatal susceptibility to cycloheximide of mice bearing Ehrlich ascites tumours and of animals pretreated with cell-free Ehrlich ascites tumour fluid. Journal of Comparative Pathology 99(3): 309-315, 1988

Neurosecretion in Ehrlich ascites carcinoma-bearing mice. Experientia 28(6): 676-677, 1972

The effect of chitosan molecular weight on the characteristics of spray-dried methotrexate-loaded chitosan microspheres for nasal administration. Drug Development and Industrial Pharmacy 35(3): 379-386, 2008