+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Methylation and gene mutation in eukaryotic DNA



Methylation and gene mutation in eukaryotic DNA



Acta Biologica Hungarica 49(2-4): 185-191



5-methylcytosine (m5C) as a rare base exists in eukaryotic genomes, which is a normal constitution in many eukaryotic DNA and the existence of m5C is a feature of eukaryotic DNA. Under regular physiological conditions, cytosine of eukaryotic DNA is usually methylated. Up to the present, many people consider that the m5C may be mutation hotspots by the deamination leading to gene mutation. Our study indicated that the spontaneous mutation caused by the transition of G.C --> A.T, in eukaryotic DNA, may result from the tautomer changing of base pairs and may also be cause by other factor actions, however it could not be caused by the deamination of m5C.

(PDF emailed within 1 workday: $29.90)

Accession: 046676986

Download citation: RISBibTeXText

PMID: 10526960


Related references

DNA Methylation and Gene Regulation || Eukaryotic DNA Methylases and Their Use for in vitro Methylation. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 326(1235): 189-198, 1990

Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene. Oncogene 19(12): 1564-1571, March 16, 2000

Eukaryotic DNA methylation and gene expression. Current Topics in Cellular Regulation 30: 1-21, 1989

DNA methylation--a regulatory signal in eukaryotic gene expression. Journal of General Virology 57(Pt 1): 1-20, 1981

Dna methylation and developmental regulation of eukaryotic globin gene transcription. Razin, A , H Cedar And A D Riggs (Ed ) Springer Series in Molecular Biology: Dna Methylation Biochemistry And Biological Significance Xiii+392p Springer-Verlag: New York, N Y , Usa: Berlin, West Germany Illus 249-268, 1984

Eukaryotic gene inactivation by sequence specific promoter methylation and the release of the transcription block. Kahl, G (Ed ) Architecture Of Eukaryotic Genes; Symposium on Chromatin Structure Of Plant Genes, Frankfurt Am Main, West Germany, September 1986 Xiv+518p Vch Publishers: New York, New York, Usa; Vch Verlagsgesellschaft Mbh: Weinheim, West Germany Illus 409-418, 1988

A gene essential for De Novo methylation and development in ascobolus reveals a novel type of eukaryotic DNA methyltransferase structure. Cell. 91(2): 281-290, 1997

Gene-specific methylation profiles in BRCA -mutation positive and BRCA -mutation negative male breast cancers. Oncotarget 9(28): 19783-19792, 2018

Relationship between point gene mutation, chromosomal abnormality, and tumour suppressor gene methylation status in colorectal adenomas. Journal of Pathology 210(3): 344-350, 2006

Use of restriction enzymes to study eukaryotic DNA methylation: I. The methylation pattern in ribosomal DNA from Xenopus laevis. Journal of Molecular Biology 118(1): 27-47, 1978

RNA methylation and control of eukaryotic RNA biosynthesis. Effects of cycloleucine, a specific inhibitor of methylation, on ribosomal RNA maturation. European Journal of Biochemistry 74(1): 19-29, 1977

Use of restriction enzymes to study eukaryotic dna methylation part 1 the methylation pattern in ribosomal dna from xenopus laevis. Journal of Molecular Biology 118(1): 27-48, 1978

Point mutation generates constitutive expression of an inducible eukaryotic gene. Proceedings of the National Academy of Sciences of the United States of America 82(3): 643-647, 1985

Possible origin and evolution of eukaryotic dna methylation methylation of cytosine residues in three palindromic families ryry yyrr yyryrr. Molekulyarnaya Biologiya 24(1): 23-43, 1990

Mutation of the RDR1 gene caused genome-wide changes in gene expression, regional variation in small RNA clusters and localized alteration in DNA methylation in rice. Bmc Plant Biology 14: 177, 2014