+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Modulation of synaptic transmission in hippocampal CA1 neurons by a novel neurotoxin (beta-pompilidotoxin) derived from wasp venom

Modulation of synaptic transmission in hippocampal CA1 neurons by a novel neurotoxin (beta-pompilidotoxin) derived from wasp venom

Neuroscience Research 41(4): 365-371

ISSN/ISBN: 0168-0102

PMID: 11755223

We examined the effects of beta-pompilidotoxin (beta-PMTX), a neurotoxin derived from wasp venom, on synaptic transmission in the mammalian central nervous system (CNS). Using hippocampal slice preparations of rodents, we made both extracellular and intracellular recordings from the CA1 pyramidal neurons in response to stimulation of the Schaffer collateral/commissural fibers. Application of 5-10 microM beta-PMTX enhanced excitatory postsynaptic potentials (EPSPs) but suppressed the fast component of the inhibitory postsynaptic potentials (IPSPs). In the presence of 10 microM bicuculline, beta-PMTX potentiated EPSPs that were composed of both non-NMDA and NMDA receptor-mediated potentials. Potentiation of EPSPs was originated by repetitive firings of the presynaptic axons, causing summation of EPSPs. In the presence of 10 microM CNQX and 50 microM APV, beta-PMTX suppressed GABA(A) receptor-mediated fast IPSPs but retained GABA(B) receptor-mediated slow IPSPs. Our results suggest that beta-PMTX facilitates excitatory synaptic transmission by a presynaptic mechanism and that it causes overexcitation followed by block of the activity of some population of interneurons which regulate the activity of GABA(A) receptors.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 046706440

Download citation: RISBibTeXText

Related references

Synaptic potentiation in CA1 hippocampal neurons byh a novel neurotoxin from wasp venom. Neuroscience Research Suppl (22): S102, 1998

Alpha-pompilidotoxin (alpha-PMTX), a novel neurotoxin from the venom of a solitary wasp, facilitates transmission in the crustacean neuromuscular synapse. Neuroscience Letters 238(3): 99-102, 1997

Effect of a novel wasp toxin beta-PMTX on the synaptic transmission of hippocampal CA1 pyramidal neurons. Society for Neuroscience Abstracts 25(1-2): 729, 1999

The neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) alters hippocampal excitatory synaptic transmission by modulation of the GABAergic system. Frontiers in Cellular Neuroscience 9: 299, 2015

Brain-Derived Neurotrophic Factor Rapidly Enhances Synaptic Transmission In Hippocampal Neurons Via Post-Synaptic TRK Receptors. Society for Neuroscience Abstracts 21(1-3): 280, 1995

Extracellular pH modulation of excitatory synaptic transmission in hippocampal CA3 neurons. Journal of Neurophysiology 123(6): 2426-2436, 2020

SNAP-29-mediated modulation of synaptic transmission in cultured hippocampal neurons. Journal of Biological Chemistry 280(27): 25769-25779, 2005

Nicotinic modulation of glutamate and GABA synaptic transmission of hippocampal neurons. Annals of the New York Academy of Sciences 868: 591-610, 1999

NT-3 regulates BDNF-induced modulation of synaptic transmission in cultured hippocampal neurons. Neuroreport 12(12): 2635-2639, 2001

Ethanol modulation of excitatory and inhibitory synaptic transmission in monkey hippocampal neurons. Alcoholism Clinical and Experimental Research 24(5 Suppl): 8A, 2000

Modulation of excitatory synaptic transmission in rat hippocampal CA3 neurons by triphenyltin, an environmental pollutant. Chemosphere 120: 598-607, 2015

Glutamate-dependent astrocyte modulation of synaptic transmission between cultured hippocampal neurons. European Journal of Neuroscience 10(6): 2129-2142, 1998

Modulation of excitatory synaptic transmission by low concentrations of glutamate in cultured rat hippocampal neurons. Journal of Physiology 494: 465-477, 1996

Delta 9-tetrahydrocannabinol antagonizes endocannabinoid modulation of synaptic transmission between hippocampal neurons in culture. Neuropharmacology 46(5): 709-715, 2004

Modulation of excitatory synaptic transmission by adenosine released from single hippocampal pyramidal neurons. Journal of Neuroscience: the Official Journal of the Society for Neuroscience 16(18): 5603-5612, 1996