+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mucosal tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8 production in patients with Helicobacter pylori infection

Mucosal tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8 production in patients with Helicobacter pylori infection

Scandinavian Journal of Gastroenterology 29(5): 425-429

We investigated whether tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-8 (IL-8) are involved in the inflammatory reaction of Helicobacter pylori infection. In 23 patients with H. pylori infection and 16 patients with negative cultures for H. pylori and normal antral mucosa, the mucosal production of TNF-alpha, IL-1 beta, and IL-8 was measured in antral biopsy specimens after 23 h of in vitro culture. The levels of TNF-alpha and IL-1 beta appeared to be significantly higher in H. pylori-positive patients (p = 0.0002 for both TNF-alpha and IL-1 beta). IL-8 production was also higher in H. pylori-infected subjects, but this difference did not reach statistical significance (p = 0.057). No significant differences were found between the level of the cytokines in H. pylori-infected patients with or without duodenal ulcer disease. A strong correlation was found between the production of IL-1 beta and IL-8. The biologic effects of these cytokines may explain the conspicuous recruitment, influx, and activation of neutrophils in the gastric mucosa during H. pylori infection.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 046735796

Download citation: RISBibTeXText

PMID: 8036458

Related references

Topical duodenal and gastric mucosal production of interleukin-1 beta, interleukin-6, interleukin-8, tumor necrosis factor alfa and interleukin-2-soluble receptor in Helicobacter pylori positive and negative patients A pilot study. Gut 39(Suppl. 2): A39-A40, 1996

Mucosal Tumor Necrosis Factor-or, Interleukin-1/3, and Interleukin-8 Production in Patients with Helicobacter pylori Infection. Scandinavian Journal of Gastroenterology 29(5): 425-429, 1994

Tumor necrosis factor alpha and interleukin 1beta up-regulate gastric mucosal Fas antigen expression in Helicobacter pylori infection. Infection and Immunity 68(3): 1189-1195, 2000

Mechanism of interleukin-8 production in gastric epithelial cells stimulated by Helicobacter pylori, interleukin-1 and tumor necrosis factor-alpha. Gastroenterology 110(4 Suppl. ): A62, 1996

Serum levels of tumor necrosis factor-alpha, interleukin-6 and interleukin-8 are not increased in dyspeptic patients with Helicobacter pylori-associated gastritis. Mediators of Inflammation 13(1): 25-28, 2004

Mucosal concentrations of interleukin-1 beta, interleukin-6, interleukin-8, and tumor necrosis factor-alpha in pelvic ileal pouches. Digestive Diseases and Sciences 39(7): 1525-1531, 1994

Inhibitory effect of sofalcone on tumor necrosis factor-alpha and interleukin-1 beta production in human monocytes stimulated by Helicobacter pylori water extract. Drugs Under Experimental and Clinical Research 27(3): 103-106, 2001

Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 32(12): 1473-1477, 1991

Interleukin 2 il 2 stimulates the production of interleukin 1 beta il 1 beta interleukin 1 alpha il 1 alpha and tumor necrosis factor alpha tnf alpha from human peripheral blood mononuclear cells pbmc. Journal of Leukocyte Biology 42(5): 545, 1987

Helicobacter pylori infection enhances mucosal interleukin-1 beta, interleukin-6, and the soluble receptor of interleukin-2. International Journal of Clinical and Laboratory Research 26(3): 207-210, 1996

Mucosal expression and luminal release of interleukin-8 and tumor necrosis alpha in duodenal ulcer patients before and after eradication of Helicobacter pylori. Gastroenterology 112(4 Suppl. ): A1018, 1997

Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P. Neuropeptides 37(6): 355-361, 2003

Changes in the production of interleukin-1 beta, tumor necrosis factor-alpha and interleukin-2 in relation to the immunity in patients with pulmonary tuberculosis. Problemy Tuberkuleza 1999(4): 31-35, 1999

Evidence for the local production of interleukin 1 beta interleukin 6 interleukin 8 and tumor necrosis factor alpha in cirrhotic and malignant ascites. Hepatology 14(4 Part 2): 97A, 1991

Interleukin 1 beta, interleukin 6, tumor necrosis factor alpha, and interleukin 10 responses in peripheral blood mononuclear cells of cynomolgus macaques during acute infection with SIVmac251. Aids Research and Human Retroviruses 12(3): 241-250, 1996