+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

National Institute of Child Health and Development Conference summary: amniotic fluid biology--basic and clinical aspects



National Institute of Child Health and Development Conference summary: amniotic fluid biology--basic and clinical aspects



Journal of Maternal-Fetal Medicine 10(1): 2-19



This report summarizes the National Institute of Child Health and Development sponsored conference on amniotic fluid (AF) biology, held 28-29 September 1999, in Detroit, Michigan. National and international investigators with expertise in AF biology addressed the regulation of AF volume and composition as well as the clinical aspects of interpreting fetal health and well-being from AF indices. A major purpose of the meeting was to consider future directions and opportunities for basic and clinical research which focus on understanding the physiology and pathophysiology and providing therapeutic interventions for abnormalities of AF volume. To achieve this, the workshop participants addressed the current state of knowledge, recent scientific advances and priorities for major questions for which answers must be sought. The fact that it is not known whether AF volume is regulated or what volume-regulatory mechanisms might be involved is a major problem that needs addressing. In the later half of gestation, potential AF volume-regulatory pathways include the two major inflows into the amniotic compartment, i.e. fetal urine and lung liquid, and the two major outflows, i.e. fetal swallowing and intramembranous absorption. If AF volume is regulated, then this must occur through regulation of intramembranous flow, because the other three flows are regulated by the fetus to meet fetal needs. Regulation of AF composition is similarly unknown. In clinical practice, a variety of ultrasonographic indices of AF volume are used, but the relationships of these indices to AF volume have not been determined, nor have their dependency on fetal size, shape or position within the uterus. Further, although aberrations in AF volume both above and below normal are associated with increased fetal and neonatal morbidity and mortality, the predictive utility of the various AF indices remains low and there is little consensus on which is best utilized under conditions of oligohydramnios, normal AF volumes, or polyhydramnios. Further, various clinical AF therapies remain largely experimental and their optimization and utilization need exploration. This report is a condensation of the views presented by the conference participants.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 046764349

Download citation: RISBibTeXText

PMID: 11332413


Related references

National Institute of Child Health and Development Conference summary: Amniotic fluid biology - basic and clinical aspects. Journal of Maternal-Fetal and Neonatal Medicine 10(1): 2-19, 2001

Biological implications of bi-directional fetomaternal cell traffic: a summary of a National Institute of Child Health and Human Development-sponsored conference. Journal of Maternal-Fetal & Neonatal Medicine 14(2): 123-129, 2003

Research on prevention of Bilirubin-Induced Brain Injury and Kernicterus: National Institute of Child Health and Human Development conference executive summary. Pediatrics 114(1): 229-233, 2004

Home monitoring of uterine contractility summary of a workshop sponsored by the national institute of child health and human development and the bureau of maternal and child health and resources development bethesda maryland usa march 29 and 30 1989. American Journal of Obstetrics & Gynecology 165(1): 2-6, 1991

Home monitoring of uterine contractility. Summary of a workshop sponsored by the National Institute of Child Health and Human Development and the Bureau of Maternal and Child Health and Resources Development, Bethesda, Maryland, March 29 and 30, 1989. American Journal of Obstetrics and Gynecology 165(1): 2-6, 1991

Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke. Pediatrics 120(3): 609-616, 2007

Proceedings of a conference of the national institute of child health and human development national institutes of health on somatic cell hybridization winter park florida usa march 11 14 1973. Davidson, Richard L And Felix F De La Cruz (Ed ) A Monograph Of National Institute Of Child Health And Human Development Somatic Cell Hybridization Symposium Winter Park, Fla , March 11-14, 1973 Xvii+295p Illus Raven Press Books: New York, N Y , U S A 1-281, 1974

Sunlight, ultraviolet radiation and the skin: summary of the National Institute of Health Consensus Development Conference. Harefuah 120(2): 102-104, 1991

National institute of child health and human development conference on development of host defenses may 1976. Cooper, Max D And Delbert H Dayton (Ed ) Monograph Of The National Institute Of Child Health And Human Development Development Of Host Defenses Conference, May 1976 Xiv+306p Illus Raven Press: New York, N Y , Usa Isbn 0-89004-117-2 1-302, 1977

Proceedings of a conference of the national institute of child health and human development on genetic counseling. Lubs, Herbert A And Felix De La Cruz (Ed ) Genetic Counseling A Monograph Of The National Institute Of Child Health And Human Development Proceedings Of A Conference Xvii+598p Illus Raven Press: New York, N Y , Usa Isbn 0-89004-150-4 1-581, 1977

Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop. Journal of Pediatrics 148(2): 170-175, 2006

Preeclampsia--a pressing problem: an executive summary of a National Institute of Child Health and Human Development workshop. Reproductive Sciences 14(6): 508-523, 2007

National Institute of Child Health and Human Development, The Consensus Development Conference on Antenatal Diagnosis. Part III: predictors of fetal distress. Pediatric Annals 9(7): 276-278, 1980

National Institute of Child Health and Human Development. The Consensus Development Conference on Antenatal Diagnosis. Part II: predictors of fetal maturation. Pediatric Annals 9(1): 62-63, 1980

Five-year plan for nutrition research and training: executive summary. National Institute of Child Health and Human Development. Pediatric Research 32(1): 1-9, 1992