New 1 alpha,25-dihydroxy vitamin D3 analogues with side chains attached to C-18: synthesis and biological activity
Grue-Sørensen, G.; Hansen, C.M.
Bioorganic and Medicinal Chemistry 6(11): 2029-2039
1998
ISSN/ISBN: 0968-0896
PMID: 9881094
DOI: 10.1016/s0968-0896(98)00161-8
Accession: 046788394
A new class of analogues of 1 alpha,25-dihydroxy vitamin D3 has been synthesised, in which the side chain (C-23 to C-27) has been removed and where new hydroxylated side chains have been attached to the C-18 methyl group. These analogues show antiproliferative activity in U937 and HaCaT cells comparable to that of 1 alpha,25-dihydroxy vitamin D3. Lack of calcemic activity makes these analogues potentially useful in the treatment of proliferative diseases.
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